RETINOBLASTOMA IN NWFP, PAKISTAN

Muhammad Arif, Zafar Iqbal, Zia -ul- Islam

Abstract


Background: Retinoblastoma is a malignant intraocular tumour of childhood, if not detected early, it
results in loss of eye as well as life. The Objective was to study the pattern of presentation of
Retinoblastoma in order to detect the disease at an earlier stage. It was conducted at Supra Regional
Referral Centre for Retinoblastoma, Department of Ophthalmology, Khyber Teaching Hospital,
Peshawar, Pakistan from 1st July 1999 to 30th September 2002. Methods: Seventy patients were
registered and admitted for diagnostic evaluation. After initial interview a proforma was filled about
history of disease. Examination under anaesthesia included indirect ophthalmoscopy with indentation.
B-scan of the eye and CT scan of the Orbit was done when required. Results: Forty (57.14%) patients
presented with Leukocoria; other presentation included hyphaema, strabismus, proptosis, 56.48%
patients presented in stage VB (Rees Elsworth classification). Conclusion: Early detection through
better understanding of presenting features of the disease and application of diagnostic skills can reduce
the advanced stage of Retinoblastoma.
Keywords: Retinoblastoma, Leukocoria, strabismus, proptosis, B-scan, Rees Elsworth classification

Full Text:

PDF

References


Pendergrass TW, Davis S. Incidence of Retinoblastoma in USAArch Ophthalmol 1980;98:1204–10.

Tamboli A, Podgor MJ, Horm JW. The incidence of

Retinoblastoma in the United States: 1974 through 1985. Arch

Ophthalmol 1990;97:1143–7.

Tarkanen A, Tuorinen E. Retinoblastoma in Finland: 1912–1964.

Acta Ophthalmologica 1971;49:293–300.

San SM, Lee SB, Au Eong KG and Chia KS. Incidence and

Survival characteristics of Retinoblastoma in Singapore from

-1995. J Pediatr Ophthalmol Strabismus 2000;37(2):87–93.

Onder F. Retinoblastoma in Turkey. J Community Eye Health

;17(1–3):2–4.

Abromson D, Ellsworth RJ. Retinoblastoma: Survival, Age at

detection and comparisons 1914-58; 1958-83. Ped Opthalmol

Strabismus 1985;22:246–50.

Kodilinye HC. Retinoblastoma in Nigeria: Problems of treatment.

Am J Opohthalmol 1967;63:469–81.

Klauss V. Retinoblastoma in developing countries. Community

Health 1990;3(5):1–2.

Kayembe-Lubeji D.Retinoblastoma in Zaire. Tropical Doctor

;20:38.

Kingston JE, Hungerford JL. Retinoblastoma: Paediatric

Oncology, 2nd Ed. Pinkerton CR and Plowman PN (Eds).

Chapman and Hall, London 1997;357.

Shields JA, Shields CL. Introcular tumours. A Text and Atlas.

Philadelphia, pa; WB Saunders Co; 1992:305–91.

CHAR DH Hedges TR Norma D. Retinoblastoma. C.T.

diagnosis Ophthalmology 1994;91:1349.

Shields JA, Leonard BC, Michaelson JB Sarin LK. B-scan

ultrasonography in diagnosis of atypical Retinoblastoma. Can J

Ophthalmolo 1976;11:1251.

DH Abramson. The Diagnosis of retinoblastoma. Bulletin of the

New York Academy of Medicine. Bull NY Acad Med

;64(4): 283–317.

C Leal-Leal, M Flores-Rojo, A Medina-Sansón, F CerecedoDíaz, S Sánchez-Félix, O González-Ramella, F Pérez-Pérez

et al. A multicentre report from the Mexican Retinoblastoma

Group. Br J Ophthalmol. 2004;88(8):1074–7.

Ozkan A, Pazarli H, Celkan T, Karaman S, Apak H, Kaner G,

Uzel O, Yildiz I. Retinoblastoma in Turkey: survival and

clinical characteristics 1981–2004. Pediatr Int

;48(4):369–73.

Mullaney PB, Karcioglu ZA, al-Mesfer S, Dowaidi M.

Retinoblastoma referral patterns in Saudi Arabia. Ophthalmic

Epidemiol 1996;3(1):35–46.

E Broaddus, A Topham, A D Singh. Clinical science

Incidence of retinoblastoma in the USA: 1975–2004. Br J

Ophthalmol 2009;93:21–3.

B M Sanders, G J Draper and J E Kingston. Retinoblastoma

in Great Britain 1969-80: incidence, treatment, and survival.

Br J Ophthalmol 1988;72:576–83.


Refbacks

  • There are currently no refbacks.


Contact Number: +92-992-382571

email: [jamc] [@] [ayubmed.edu.pk]