Shamsunnisa Sadia, Fareesa Waqar, Tasneem Akhtar, Sadia Sultana


Background: Ovulatory dysfunction is a group of disorders with variable clinical presentations
occasionally having serious long-term adverse effects. It accounts for 30% of female fertility problems.
Evidence suggests an association between an individual’s weight and disorders of ovulation. The
objective of our study was to describe the clinical and hormonal profile of subfertile women with
ovulatory dysfunction in relation to their body mass index (BMI). Methods: This prospective,
descriptive study was carried out in Mother and Child Health Centre, PIMS, Islamabad and Railway
hospital, Rawalpindi from April 2001 to March 2007. One hundred & thirty eight infertile patients with
ovulatory dysfunction were included. The clinical data including BMI of each patient was recorded in
addition to reports of investigations comprised of cervical smear, pelvic ultrasound and hormonal
profile. Results: Primary infertility was found in 61% while secondary in 39% of the patients. The
mean age was 29 years and mean duration of infertility was 6 years. Menstrual pattern was normal in
56.5%. BMI was normal in 30.4% while most patients were overweight and obese. Prolonged cycles,
history of systemic endocrine disorders, abnormal vaginal discharge, hirsutism, polycystic ovarian
morphology and hormonal abnormalities were more frequent in patients with increased BMI. During
the study period, 21.7% of the women conceived. Conclusion: Infertile patients with ovulatory
dysfunction present more frequently with primary infertility. They usually have higher than required
BMI. Oligomenorrhoea amenorrhoea, hirsutism and hormonal abnormalities are more frequent in
overweight than infertile patients with ovulatory dysfunction having a normal BMI.
Keywords: Infertility, Ovulatory Dysfunction, Clinical Characteristics, Body mass index, BMI

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