Farhana Shahzad, Shahzad Tawwab, Afia Abbas


Objectives: To find any association of white blood cells, haemoglobin and ESR with ischemic heart
disease in high risk native population. Methodology: The study included 93 male patients with
Ischemic heart disease, between 40 and 60 years of age; 96 age and gender matched subjects. All
study participants were non-diabetics. Complete blood cells count, haemoglobin and ESR levels
were compared between the patient and control groups. Results: Total leukocyte counts along with
neutrophils were significantly higher in the test group compared to the control population (p<0.001)
and lymphocytes were significantly lower (p<0.001) in the patient group as compared to the control
group. Haemoglobin levels were significantly lower (p<0.001) and ESR was higher (p=0.030) in the
patient group as compared to the control group. Conclusion: Although, our findings of the study
variables extend previous reports, the prevalence and prognostic importance of theses variables in
IHD should be assessed in future experimental studies. These parameters could be important in
public health because they are routinely measured by clinicians and may be helpful to predict the risk
of future and secondary ischemic events in a high risk population.
Keywords: TLC, DLC, Haemoglobin, ESR, Ischemic Heart Disease

Full Text:



Ounpuu S, Anand S, Yusuf S. The global burden of

cardiovascular disease. Medscape Cardiology. Available from

Jia E, Yang Z, Yuan B, Zang X, Wang R, Zhu T, Wang L, Chen

B, Ma W. Relationship between leukocyte count and

angiographical charateristics of coronary atherosclerosis. Acta

Pharmacologica Sinica 2005;26(9):1057–62.

Sweetnam PM, Thomas HF, Yarnell JW, Baker IA, Elwood PC.

Total and Differential Leukocyte Counts as predictors of

ischemic heart disease: The Caerphilly and Speedwell Studies.

Am J Epidemiol 1997;145:416–21.

Weijenberg MP, Feskens EJ, Kromhout D. White blood cell

count and the risk of coronary heart disease and all-cause

mortality in elderly men. Arterioscler Thromb Vasc

Biol 1996;16:499–503.

Hansson GK. Inflammation, atherosclerosis and coronary artery

disease. N Engl J Med 2005;352:1685–95.

Madjid M, Awan I, Willerson J T, Casscells S W. Leukocyte

count and coronary heart disease. J Am Coll Cardiol


Zeidman A, Zinaida F, Blecher A, Oster HS, Avrahami Y,

Mittelman M. Anemia as a risk factor for ischemic heart disease.

IMAJ 2004;6:16–8.

Dijk JM, Wangge G, van der Graaf Y, Bots ML, Grobbee D.E,

Algra A. Hemoglobin and atherosclerosis in patients with

manifest arterial disease The SMART-Study. Atherosclerosis


Arant CB, Wessel TR, Olson MB, Merz CN, Sopko J, Rogers

WJ, et al. Hemoglobin level is an independent predictor for

adverse cardiovascular outcomes in women undergoing

evaluation for chest pain. J Am Coll Cardiol 2004;43:2009–14.

Natali A, L’ Abbate A, Ferrannini E. Erythrocyte sedimentation

rate, coronary atherosclerosis, and cardiac mortality. Eur Heart J


Danesh J, Collins R, Peto R, Lowe GD. Haematocrit, viscosity,

erythrocyte sedimentation rate: meta-analysis of prospective

studies of coronary heart disease. Eur Heart J 2000;21:515–20.

Erikssen G, Liestol K, Bjornholt JV, Stormorken H, Thaulow E,

Erikssen J. Erythrocyte sedimentation rate: a possible marker of

atherosclerosis and a strong predictro of coronary heart disease

mortality. Eur Heart J 2000;21:1614–20.

Report of the Expert Committee on the Diagnosis and

Classification of Diabetes Mellitus. Diabetes Care

; 20:1183–97.

Wheeler JG, Mussolino ME, Gillum RF, Danesh J. Associations

between differential leukocyte count and incident coronary heart

disease: 1764 incident cases from seven prospective studies of

individuals. Eur Heart J 2004;25:1287–92.

Grau AJ, Boddy AW, Dukovic DA, Buggle F, Lichy C, Brandt

T, Hacke W. Leukocyte count as an independent predictor of

recurrent ischemic events. Stroke 2004;35:1147–52.

Zouridakis EG, Garcia-Moll X, Kaski JC. Usefulness of the

blood lymphocyte count in predicting recurrent instability and

death in patients with unstable angina pectoris. Am J Cardiol


Ommen SR, Gibbons RJ, Hodge DO, Thomas SP. Usefulness of

the lymphocyte concentration as a prognostic marker in coronary

artery disease. Am J Cardiol 1997;79:812–4.

Knoflach M, Kiechl S, Mayr A, Willeit J, Poewe W, Wick G.

Allergic Rhinitis, Asthma, and Atherosclerosis in the Bruneck

and ARMY studies. Arch Intern Med 2005;165:2521–6.

Sarnak M.J, Tighiouart H, Manjunath G, MacLeod B, Griffith J,

Salem D, Levey A.S. Anemia as a risk factor for cardiovascular

disease in the atherosclerosis risk in communities (aric) study. J.

Am. Coll. Cardiol.2002;40:27–33.


  • There are currently no refbacks.

Contact Number: +92-992-382571

email: [jamc] [@] []