UPFRONT NEPHRECTOMY VERSUS PREOPERATIVE CHEMOTHERAPY IN WILM’S TUMOUR

Authors

  • Ruqayya Manzoor Children's Hospital, Pakistan Institute of Medical Sciences, Islamabad
  • Nuzhat Yasmeen Childrens Hospital, Pakistan Institute of Medical Sciences, Islamabad

Abstract

Background: Wilms tumour is the most common renal tumour in paediatric age group. This study was done to compare the two approaches used for treatment, namely upfront nephrectomy versus pre-operative chemotherapy. Methods; A descriptive cross-sectional study was done enrolling all the patients of Wilms tumour reporting to Oncology unit Children’s Hospital during the study period. A total of 80 patients were divided into 2 groups. One group (n=40) had upfront surgery while the other (n=40) received pre-op chemotherapy before surgery. Both groups were compared for outcomes including whether treatment completed and declared cured, lost during treatment against medical advice, or died during treatment.  Results; It was found that stage 2 patients were more likely to get upfront surgery done while stage 3,4 and 5 were likely to get pre-operative chemotherapy before nephrectomy. Also, favourable histology was associated with better outcome overall outcome.Keywords: Wilms tumour; Nephrectomy; Chemotherapy; Preoperative Chemotherapy

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Published

2019-01-13

Issue

Vol. 31 No. 1 (2019): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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