ASSOCIATION OF LIPOPROTEIN-α WITH OBESITY IN CHILDREN AND ADOLESCENTS IN DISTRICT SWAT

Syed Motahir Ali Shah, Mian Ihsanullah, Abdur Rasheed

Abstract


Background: Studies have demonstrated that atherosclerosis has its silent beginning during
childhood. Coronary artery disease, particularly when it presents early in adult life has been observed
to have a familial tendency. Lipoprotein-α [Lp-α], has a strong genetic association and raised levels
when combined with obesity increase the risk of premature coronary heart disease. Thus in adults,
has emerged the possibility of preventing or delaying the coronary artery disease when appropriate
measures are applied early in life. In our study, we assessed the prevalence of overweight and obesity
and its association with Lp-α in the child population of district Swat. Methods: The study was
carried out in Saidu Teaching Hospital and Biochemistry Department, Saidu Medical College, Swat,
from May to July 2007. Both boys and girls between 10–20 years of age were included. The
prevalence of obesity was detected in 200 subjects by using body mass index. One hundred subjects
were selected to compare the anthropometric and cardiovascular parameters of obese subjects with
control group. Lp-α was measured in children of both the groups. Results: The prevalence of obesity
in adolescent boys was 6.7% and that in adolescent girls was 10%. The prevalence was higher in
female subjects, compared to male subjects. Obese subjects had significantly higher weight, body
mass index, blood pressure values and Lp-α levels as compared to control group. Conclusion:
Lipoprotein-α level is higher in obese children and adolescents than in non-obese.
Keywords: Lipoprotein-α, Lp-α, Body mass index (BMI), Blood pressure (BP), Obesity

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