EFFECT OF FICUS RELEGIOSA ON BLOOD GLUCOSE AND TOTAL LIPID LEVELS OF NORMAL AND ALLOXAN DIABETIC RABBITS

Authors

  • Noreen Wadood
  • Abdul Wadood
  • Mohammed Nisar

Abstract

Background:The present study was planned to observe the hypoglycemic effect of the ‘Ficus relegiosa’, a traditional medicinal plant. This study was performed to study the possible role of indigenous medicinal plants in the treatment of Diabetes mellitus (type-2) Methods: Normal rabbits were divided into 5 groups (1-5) of six animals each. Group 1 served as control and received 15 ml of water only. Group 2 received tolbutamide 500-mg/Kg body weight. Group 3-5 received the extract of Ficus relegiosa dissolved in 15ml of water in doses of 200 mg/Kg, 250 mg/Kg and 300mg/Kg body weight respectively. The diabetic rabbits were also divided in 5 groups on the same pattern.  The blood glucose and total lipid levels were estimated before and 1,2, 3 and 4 hours after the administration of the extract. Results: The extract exerted a significant (P< 0.05) hypoglycemic effect in normal rabbits, which was however short lived. The hypoglycemic effect was not significant (P> 0.05) in alloxan treated rabbits. The extract had no significant effect (P> 0.05) on total lipid levels in normal as well as in alloxan-treated diabetic rabbits. The doses used did not show acute toxicity or result in behavioral changes. Conclusion:  From this study it may be concluded that the extract acts by initiating the release of insulin by pancreatic beta cells of normal rabbits.

References

Said, M, Hamdard Pharmacopoeia of Eastern Medicine, 2nd ed. Hamdard National Foundation, Karachi, 53-54. 1970

Augusti KT, Benaim ME. Effect of essential oil of onion (APDS) on blood glucose, free fatty acids and insulin levels of normal subjets. Clin Chim Act 1975; 60:121-123.

Marquis VO, Adanlwo TA, Olaniyi AA. The effect of foetidin from Momordica foetida on blood glucose of albino rats. Planta Med. 1977; 31: 367-74.

Khan AKA, Akhtar MS, Mehtab H. The treatment of diabetes mellitus with Coccinia indica. British Med Jour 1980;280:1044-46.

Akhtar MS, Athar MA, Yaqub M. Effect of Momordica charantia on blood glucose levels of normal and alloxan diabetic rabbits, Planta Med. 1981;42: 205-12.

Akhtar MS, Ali MR. Study of hypoglycemic activity of Cuminum nigrum seeds in normal and alloxan diabetic rabbits. Planta Med 1985; 51: 81-5.

William, D, Pharmacographica Indica, P-415; Hamdard National Foundation, Karachi. 1972

Brahmchari, HD, Augusti, KT. Pharmacological screening of medicinal plants. Indian Journal Physiol Pharmacol 1992;8(1) 60-64

Qayum A, Ahmed N, Ahmed KD, Khattak SG. Pharmacological screening of medicinal plants. J Pak Med Assoc 1982; 32: 103-5.

Winckers J. Blood glucose its determination. In: Varley practical clinical Biochemistry by 5th ed. London Heinemann, 1980; 396-7

Akhtar MS, Khan QM, Khaliq T. Effect of Euporrbia Prostrata and Fumaria parvifora in normoglycaemic and alloxan-treated hyperglycemic rabbits. Planta Med 1984; 66:138-42.

John HK, Katzung BC. Pancreatic hormones and antidiabetic drugs. In: Basic and clinical pharmacology 6th Ed. USA; Prentice Hall, 1995; 545-637.

Wadood N, Wadood A, Hidayat HK, Wahid SWA. Effect on Eriobotrya japonica on blood glucose levels of normal and alloxan diabetic rabbits. Planta Med 1988;25:1-6.

Wadood A, Wadood N, Shah SAW. Effects of Acacia arabica and Caralluma edulis on blood glucose levels of normal and alloxan diabetic rabbits. J Pak Med Assoc 1989; 39:208-12.

Jim, M, and ball, M, Hyperlipidaemia, Med J. Inter. 1985; 5; 580-584