Noreen Wadood, Abdul Wadood, Mohammed Nisar


Background:The present study was planned to observe the hypoglycemic effect of the ‘Ficus relegiosa’, a traditional medicinal plant. This study was performed to study the possible role of indigenous medicinal plants in the treatment of Diabetes mellitus (type-2) Methods: Normal rabbits were divided into 5 groups (1-5) of six animals each. Group 1 served as control and received 15 ml of water only. Group 2 received tolbutamide 500-mg/Kg body weight. Group 3-5 received the extract of Ficus relegiosa dissolved in 15ml of water in doses of 200 mg/Kg, 250 mg/Kg and 300mg/Kg body weight respectively. The diabetic rabbits were also divided in 5 groups on the same pattern.  The blood glucose and total lipid levels were estimated before and 1,2, 3 and 4 hours after the administration of the extract. Results: The extract exerted a significant (P< 0.05) hypoglycemic effect in normal rabbits, which was however short lived. The hypoglycemic effect was not significant (P> 0.05) in alloxan treated rabbits. The extract had no significant effect (P> 0.05) on total lipid levels in normal as well as in alloxan-treated diabetic rabbits. The doses used did not show acute toxicity or result in behavioral changes. Conclusion:  From this study it may be concluded that the extract acts by initiating the release of insulin by pancreatic beta cells of normal rabbits.

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Said, M, Hamdard Pharmacopoeia of Eastern Medicine, 2nd ed. Hamdard National Foundation, Karachi, 53-54. 1970

Augusti KT, Benaim ME. Effect of essential oil of onion (APDS) on blood glucose, free fatty acids and insulin levels of normal subjets. Clin Chim Act 1975; 60:121-123.

Marquis VO, Adanlwo TA, Olaniyi AA. The effect of foetidin from Momordica foetida on blood glucose of albino rats. Planta Med. 1977; 31: 367-74.

Khan AKA, Akhtar MS, Mehtab H. The treatment of diabetes mellitus with Coccinia indica. British Med Jour 1980;280:1044-46.

Akhtar MS, Athar MA, Yaqub M. Effect of Momordica charantia on blood glucose levels of normal and alloxan diabetic rabbits, Planta Med. 1981;42: 205-12.

Akhtar MS, Ali MR. Study of hypoglycemic activity of Cuminum nigrum seeds in normal and alloxan diabetic rabbits. Planta Med 1985; 51: 81-5.

William, D, Pharmacographica Indica, P-415; Hamdard National Foundation, Karachi. 1972

Brahmchari, HD, Augusti, KT. Pharmacological screening of medicinal plants. Indian Journal Physiol Pharmacol 1992;8(1) 60-64

Qayum A, Ahmed N, Ahmed KD, Khattak SG. Pharmacological screening of medicinal plants. J Pak Med Assoc 1982; 32: 103-5.

Winckers J. Blood glucose its determination. In: Varley practical clinical Biochemistry by 5th ed. London Heinemann, 1980; 396-7

Akhtar MS, Khan QM, Khaliq T. Effect of Euporrbia Prostrata and Fumaria parvifora in normoglycaemic and alloxan-treated hyperglycemic rabbits. Planta Med 1984; 66:138-42.

John HK, Katzung BC. Pancreatic hormones and antidiabetic drugs. In: Basic and clinical pharmacology 6th Ed. USA; Prentice Hall, 1995; 545-637.

Wadood N, Wadood A, Hidayat HK, Wahid SWA. Effect on Eriobotrya japonica on blood glucose levels of normal and alloxan diabetic rabbits. Planta Med 1988;25:1-6.

Wadood A, Wadood N, Shah SAW. Effects of Acacia arabica and Caralluma edulis on blood glucose levels of normal and alloxan diabetic rabbits. J Pak Med Assoc 1989; 39:208-12.

Jim, M, and ball, M, Hyperlipidaemia, Med J. Inter. 1985; 5; 580-584


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