CNS TUMORS AT AKU: AN UPDATE PLUS A BRIEF DISCUSSION ON INTRAVENTRICULAR TUMORS WITH SPECIAL EMPHASIS ON CENTRAL NEUROCYTOMA.

Authors

  • Z Ahmed
  • NS Azad
  • S Muzaffer
  • SH. Hasan

Abstract

Background: This paper is intended to be an update of our earlier published work on CNS tumors along with additional information on intraventricular tumors. Three cases of central neurocytoma are also discussed. Methods: An analysis conducted in the Section of Histopathology, AKU to determine the frequency of all CNS neoplasms diagnosed between Jan 1, 1994 and Dec 31, 2001. Frequency of intraventricular tumors was also determined. Histological characterization of the tumors was based on the WHO and AFIP (USA) classification systems for CNS tumors. Results: A total of 1677 CNS tumors were diagnosed during the study period. 1510(90.04%) were primary, and 167(9.96%) were metastatic. Among the primary tumors, gliomas constituted the largest category with 825 cases or 54.63% of all primary tumors. Meningothelial tumors comprised the second largest group with 364 cases or 24.10%. among other major categories, embayonal tumors, and peripheral nerve sheath tumors comprised 6.75% and 6.82% of all primary tumors. Among less common tumors, Non-Hodgkin’s lymphomas and hemangioblastomas comprised 3.11% and 1.52% of all CNS tumors. Intraventricular tumors comprised 7.41% of all primary tumors. Ependymomas comprised 64.28% of all Intraventricular tumors. Conclusions: Gliomas and meningothelial tumors are the commonest group of primary CNS tumors. Metastatic tumors are quite common.KEY WORDS:     Gliomas, astrocytomas, meningiomas, metastatic tumors, intraventricular tumors, central neurocytoma.

References

Bhurgri Y, Bhurgri A, Hasan SH, Zaidi SHM, Rahim A, Sankaranarayanan R et al. Cancer Incidence in Karachi, Pakistan: First results from Karachi Cancer Registry. Int J Cancer 2000; 85:325-29.

Ahmed Z, Muzaffar S, Kayani N, Pervez S, Hussainy AS, Hasan SH. Histological pattern of Central Nervous System Neoplasms. J Pak Med Assoc 2001; 51:154-7.

Kleihues P, Burger PC, Scheithauer BW. Histological typing of the tumors of the Central Nervous System. World Health Organization. Berlin Springer – Verlag, 1993. P.11-14.

Burger PC, Scheithauer BW. Histological Classification of Tumors of Central Nervous System. In Burger PC, Scheithauer BW. Tumors of the Central Nervous System. Atlas of Tumor Pathology, third series. Fascicle 10. Washington DC. 1994, Armed Forces Institute of Pathology P.4-7.

Rosenfeld SS, Massey EW. Epidemiology of Primary Brain Tumor. In Anderson DW (ed): Neuroepidemiology: a tribute to Bruce Schoenberg. Boca Raton: CRC Press 1991:P121-143.

Rawlings CE, Giangaspero F, Burger PC, Bullard DE. Ependymomas. A clinicopathologic study. Surg Neurol 1988; 29:271-81.

Schiffer D, Chio A, Cravioto H. Ependymoma:internal correlations among pathological signs: the anaplastic variant. Neurosurgery 1991; 29:206-10.

Shepherd CW, Scheithauer BW, Gomez MR, Altermalt HJ, Katzmann JA. Subependymal giant cell astrocytoma: a clinical, pathological and flow cytometric study. Neurosurgery 1991; 28:864-8.

Lombardi D, Scheithauer BW, Meyer FB, Forbes GS, Shaw EG, Gibney DJ et al. Symptomatic Subependymoma. A clinicopathological and flow cytometric study. J Neurosurg 1991; 75:583-8.

Figarella-Branger D, Pellissier JF, Daumas-Duport C, Delisle MB, Pasquier B, Parent M et al. Central Neurocytomas. Clinical evaluation of a small cell neuronal tumor. Am J Surg Pathol 1992; 16:897-909.

Hassoun J, Soylemezoglu F, Gambarelli D, Figarella-Branger D, Van Ammon K, Kleihues P. Central Neurocytoma: asynopsis of clinical and histological features. Brain Pathol 1993; 3:297-306.

Yasargil MC, Von Ammon K, Von Deimling A, Valavanis A, Wichmann W, Wiestler OD. Central Neurocytoma: histopathological variants and therapeutic approaches. J Neurosurg 1992; 76:32-7.

Burger PC, Scheithaver BW. Neuronal and glioneuronal tumors. In Burger PC, Scheithauer BW. Tumors of the Central Nervous System. Atlas of Tumor Pathology, third series. Fascicle 10, Washington DC. 1994. Armed Forces Institute of Pathology. 163-192.

Nakagawa K, Aoki Y, Sakata K, Sasaki Y, Matsutani M, Akanuma A. Radiation therapy of well differentiated neuroblastoma and central neurocytoma. Cancer 1993; 72:P1350-1355

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Vol. 16 No. 4 (2004): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

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ORIGINAL ARTICLE

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