EFFECT OF NIGELLA SATIVA (KALONJI) ON SERUM CHOLESTEROL OF ALBINO RATS

Amir Hamzo Dahri, Atta Muhammad Chandio, Ali Akbar Rahoo, Rafique Ahmed Memon

Abstract


Background: The increased level of LDL-c in the serum has a high risk and the increased serum HDL-c level has a low risk for the development of atherosclerosis. The effect of Nigella Sativa on levels of cholesterol fractions were determined in this study on rats. Methods: 24 albino rats of 08 weeks age having equal number of males and females were kept at optimum atmospheric condition. The blood samples were taken at the start and different control and experimental diets were given for 20 weeks. The experimental diets were added with Nigella Sativa as 30 mg/kg body weight. The blood samples were taken at the end of study. The blood samples drawn at the start and end of the study were estimated for serum cholesterol. The results of control and experimental groups were compared. Results: Total serum cholesterol in the control group showed increase from 8.3±3.30 to 13.96±9.3 at 20 weeks. The serum HDL cholesterol showed increase from 44.4±6.12 to 80.45±5.95 level at 20 weeks. The serum LDL cholesterol showed increase from 8.3±3.30 to 13.96±9.3 at 20 weeks. The total serum cholesterol in experimental group was increased from 76.9±6.5 to 117.5± 6.65 at 20 weeks. The serum HDL cholesterol levels was increased from 41.7±4.9 to 83.42±5.92 at 20 weeks as compared with control group. The LDL cholesterol levels were decreased from 12.7±6.9 to 8.5±7.8 at 20 weeks. Conclusion: This study shows significant decrease in serum low density lipoprotein cholesterol level, and increase in serum high density lipoprotein cholesterol levels.

Keyword: Nigella Sativa, Serum Cholesterol, Rats


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References


National Institute of Health Consensus Development Conference. Lowering blood cholesterol to prevent heart disease. JAMA 1985;253:2080-6.

Park K. Parks text book of preventive and social medicine. 24th ed. Jabalpur India: Banarasi Das Bhanot, 2004: 272 - 73.

Ahmed MM, Jeyalingam K, Hassan AM, Marinah T. Dietary fats and hypercholestrolemia in an experimental model of Macaca Fascilaris. Pak Pathol 1992;3:5-10.

Rader DJ, Ikewaki K, Duverger A. Very low high density lipoproteins without coronary atherosclerosis. Lancent 1993; 342:1455-8.

Sundram K. High lights of the director general report on palm oil and human nutrition. Palm oil development 1992;16: 14-16.

Shepherd J, Packard CV, Grundy SM. Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man. J Lipid Res 1980;21:91-9.

Blatter E, Caius JF, Mhaskar KS (eds). Indian Medicinal Plants. 2nd Ed. Allahabad, India: Lalit Mohan Basu, 1984;11-12.

Saeed HM. Pharmacography Indica Hamdard 1972;15:28-29.

Akhtar MS, Riffat S. Field Trail of saussurea lappa roots against nematodes and Nigella sativa seed against cestides in children. J Pak Med Assoc 1991;41:185-7.

Panikar KR, Salomi MJ, Kesven M, Dorata SR, Rajgopalam K. Anticancer activity of Nigella sativa. Ancient science of life 1989;8: 262-78.

Ghoneim MT, El-Ginly, El-Aami R, Shouky RE, Yaseen S. Possible effects of some extracts of Negilla sativa seed on blood coagulation system and Fibrinolytic activity. Proceeding of 2nd international conference on Islamic medicine, Kuwait, 1982:528-35.

El-Dakhakhany M. Some pharmacological properties of some constituents of Negilla sativa seed. Planta Med 1982; 426-8.

Le PM,Benhaddou-Andaloussi A, Settaf A, Cherrah Y, Haddad PS. The petroleum ether extract of Nigella sativa exerts lipid powering actom in the rats. J Ethanopharmacol. 2004:94(2-3): 251-9.

Badary OA, Abdel Nain AB, Abdel Wahab MH, Hamada FM. Induced hyperlipidermic nephropathy in rats: Toxicology 2000;143(3):219-26.

El Dakha Khani M, Mady NL, Halim MA. Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittelforschung 2000;50(9);832-6.


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