EFFECT OF SITAGLIPTIN ON GLYCEMIC CONTROL, BODY WEIGHT, BLOOD PRESSURE AND SERUM LIPID PROFILE IN TYPE 2 DIABETIC HYPERLIPIDEMIC PATIENTS

Authors

  • Mazhar Hussain university of health sciences lahore
  • Moazzam Ali Atif university of health sciences lahore
  • Ali Gull Tunio
  • Barkat Ali
  • Lubna Akhtar
  • Ghulam Serwar

Abstract

Background: Dyslipidaemia is a global health issue in developed as well as in developing countries. People with type 2 Diabetes mellitus are more susceptible to develop dyslipidaemia and its related complications. The objective of the study was to assess the effect of sitagliptin a (DPP-4 inhibitor) oral antidiabetic drug on blood sugar, body weight, blood pressure and dyslipidaemia in type 2 diabetic patients. Methods: This 12 weeks open label observational study was conducted at outdoor of diabetic clinic of Sheikh Zayed Medical College/Hospital, Rahim Yar Khan in which newly diagnosed type 2 diabetic patients (n=78) with poor glycaemic control(HbA1c >7.2%) were selected. The patient received sitagliptin 50 mg twice daily for 12 weeks. Results: After 12 weeks treatment with sitagliptin, there was a significant reduction in the value of HbA1c from 8.184%±0.467 at baseline to 7.0200%±0.459 at 12 weeks (p<0.05). Body weight also decreased significantly from 80.21kg±7.156 at baseline to 71.74 kg±6.567 at 12 weeks (p<0.05).Systolic blood pressure decreased (SBP) decreased significantly from 138.17±6.050 mmHg at baseline to 131.22±6.311 mmHg at 12 weeks (p<0.05). Significant changes were also seen in diastolic blood pressure which decreased from 83.14±6.714 mmHg at baseline to 75.28±6.481 mmHg at 12 weeks (p<0.05). Significant reduction in the serum level of total Cholesterol (TC), triglycerides (TG) and Low density lipoprotein cholesterol (LDL-C) were detected (TC: 222.09±13.538 to 209.41±13.475 mg/dl, p<0.05; TG: 170.99±6.940 to 143.45±8.279 mg/dl, p<0.05; LDL-C 120.00±5.804 to 109.06±6.278 mg/dl, p<0.05). High density lipoprotein cholesterol (HDL-C) increased significantly from 42.99±4.836 mg/dl at baseline to 49.97±3.490 mg/dl at 12 weeks. Conclusion: Sitagliptin not only improves blood glucose control but also body weight, blood pressure and lipid profile in type 2 diabetic hyperlipidaemia patientsKeywords: Sitagliptin, Diabetes Mellitus, HbA1c, Blood pressure, Lipid profile, body weight

Author Biographies

Mazhar Hussain, university of health sciences lahore

Assistant professor department of pharmacology shaikh zaid medical college Rahim yar khan.

Moazzam Ali Atif, university of health sciences lahore

Professor department of pharmacology shaikh zaid medical college Rahim Yar khan.

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Published

2016-06-01

Issue

Vol. 28 No. 2 (2016): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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