RESISTANCE PATTERNS OF URINARY ISOLATES IN A TERTIARY INDIAN HOSPITAL

Azra S. Hasan, D. Nair, J Kaur, G. Baweja, M Deb, P. Aggarwal

Abstract


Background: To analyze the pathogenic organisms recovered from patients with urinary tract
infection in a tertiary Indian hospital setting along with determination of the occurrence and antimicrobial sensitivity of uropathogens on a retrospective basis during a period of one year.
Methods : A total of 5073 urine samples were processed. Urine culture was done using
conventional microbiological techniques. Biochemical testing was used to identify the organisms
and antibiotic sensitivity was done by the Kirby Bauer method. Results: A total of 2436
uropathogens were isolated. E coli were seen in 50.7% samples followed by Klebsiella sp
(27.6%). Staphylococcus aureus was the commonest Gram- positive isolate (1.5%). Urinary tract
infection (UTI) was seen in 70.5% females as compared to 29.5% males. A high recovery of
isolates was noted from July to September. Multi drug resistance was commonest with
Enterococcus (78.8%) followed by Pseudomonas (65.1%). Drugs, which retained usefulness for
Gram-negative isolates, were amikacin, norfloxacin and cefotaxime. For Gram-positive isolates,
vancomycin, teicoplanin, lincomycin and Norfloxacin were very effective. Conclusions: Our
study highlights the changing etiology of UTI and emergence of drug resistance within the Indian
subcontinent.
Keywords: Urinary Tract Infections, Pathogens, Antibiotics

Full Text:

PDF

References


Wilkie ME, Almond MK, Marsh FP. Diagnosis and

management of urinary tract infection in adults. BMJ 1992;

(6862):1137-41

Bajaj JK, Karyakarte RP, Kulkarni JD, Deshmukh AB.

Changing aetiology of urinary tract infections and emergence

of drug resistance as a major problem.

J Commun Dis. 1999 Sep;31(3):181-4.

Kass EH. Asymptomatic infections of the urinary tract. Trans

Assoc Am Physicians. 1956, 69:56-64.

Forbes BA, Sahm DF, Weissfeld AS, eds. In: Bailey and

Scott’s Diagnostic Microbiology. 10th Ed. Mosbylnc, Missouri

; 359-61.

Bauer AW, Kirby WM, Sh erris JC, Turck M. Antibiotic

susceptibility testing by a standardized single disk method.

Am J Clin Pathol. 1966 Apr;45(4):493-6.

National Committee for Clinical Lab Standards, Performance

Standardization for Antimicrobial Disc Susceptibility test. 4th

ed. Villanona PA. NCC 1993; DC M2 AS.

Tankhiwale SS, Jalgaonkar SV, Ahamad S, Hassani U.

Evaluation of extended spectrum beta lactamase in urinary

isolates. Indian J Med Res. 2004;120(6):553-6.

Chan RK, Lye WC Lee EJ, Kumarasinghe G. Nosocomial

urinary tract infection: a microbiological study.

Ann Acad Med Singapore. 1993;22(6):873-7.

Olafsson M, Kristinsson KG. Sigurdsson JA. Urinary tract

infections, antibiotic resistance and sales of antimicrobial

drugs--an observational study of uncomplicated urinary tract

infections in Icelandic women. Scand J Prim Health Care.

;18(1):35-8.

Gupta K, Scholes D, Stamm WE. Increasing prevalence of

antimicrobial resistance among uropathogens causing acute

uncomplicated cystitis in women. JAMA.1999; 281(8):736-8.

Anderson JE. Seasonality of symptomatic bacterial urinary

infections in women. J Epidemiol Community Health. 1983;

(4): 286-90.

Ram S, Gupta R, Gaheer M. Emerging antibiotic resistance

among the uropathogens. Indian J Med Sci 2000; 54(9):388-94.

Mathai E, Grape M, Kronvall G. Integrons and multidrug

resistance among Escherichia coli causing community-acquired

urinary tract infection in southern India. APMIS. 2004;

(3):159-64.

Farrell DJ, Morrissey I, De Rubeis D, Robbins M, Felmingham

D. A UK multicentre study of the antimicrobial susceptibility

of bacterial pathogens causing urinary tract infection. J Infect .

; 46(2):94-100.

Iqbal J, Rahman M, Kabir MS, Rahman M. Increasing

ciprofloxacin resistance among prevalent urinary tract bacterial

isolates in Bangladesh. Jpn J Med Sci Biol 1997; 50(6):241-50.

Huovinen P, Cars O. Control of antimicrobial resistance: time

for action. The essentials of control are already well known.

BMJ. 1998;317(7159):613-4.


Refbacks

  • There are currently no refbacks.


Contact Number: +92-992-382571

email: [jamc] [@] [ayubmed.edu.pk]