COMPARISON OF VERAPAMIL AND CIMETIDINE FOR THEIR EFFECTS ON VOLUME AND ACIDITY OF CARBACHOL INDUCED GASTRIC SECRETION IN FASTING RABBITS

Muhammad Jan, Shaukat Ali Orakzai, Shafique Tariq, Muhammad Javid, Shafiq Ahmad, Muhammad Haroon, Muhammad Qamar

Abstract


Background: Peptic ulcer is a common ailment for which over production of gastric acid is the
main cause. This study was undertaken to find out the effects of Calcium channel blocker
Verapamil and Cimetidine on volume and acidity of Carbacol induced gastric section, free and
total acidity of carbachol induced gastric secretion and their effects were also compared.
Methods: Thirty rabbits of local breed weighing 1-1.5kg were used. The animals were kept on
fasting for 48 hours after which the pylorus of each was ligated. Verapamil 10mg/kg, Cimetidine
2.5 mg/kg and Carbachol 600μg/kg body weight were administered intrapertoneally in pylorus
ligated rabbits. Results: It was found that Verapamil reduced the volume, free and total acidity of
gastric secretion, which were statistically highly significant when compared with Carbachol
(P<0.001). Cimetidine also had the same effects. when the difference of means values brought
about by verapamil were compared with those of Cimetidine, all these differences were found
statistically non significant, indicating that Verapamil has similar effect as that of Cimetidine on
all parameters included in study. Conclusion: Verapamil has significant effect on volume and
acidity of carbachol induced gastric secretion.
Keywords: Verapamil, Cimetidine, Carbachol, Gastric Secretion, Rabbit, Stomach, Acidity

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