Sajid Nazir Bhatti, Shahid Ayub, Ahsan Aurangzeb, Anwar Ul Haq, M. Jamil, Johar Ali, Ayesha Ahmad, M. Kashif


Background: Deep seated lesions of the brain cannot be approached by conventional
neurosurgical approach stereotactic system offers minimally invasive and accurate
approach to such lesions. This study was carried out with an objective to determine the
safety, efficacy and diagnostic yield of stereotactic biopsies of brain lesions using BrownRoberts-Wells (BRW) system. Methods: This study was carried out in patients with
intracranial lesions at Ayub teaching hospital Abbottabad from September 1999 to
October 2003. Suitable patients with intra cranial lesions underwent computerized stereo
tactic biopsy with BRW system. Tissue specimens were analyzed in histopathology
department of the Ayub Medical College and results were obtained. Data was analyzed
via computer software SPSS 8.0 version for windows. Results: Fifteen patients were
selected for stereotactic brain biopsy. Age ranged from 15 years to 54 years. Among them
09 (60%) were male and 06 (40%) were female patients. Out come of the procedure was
highly promising in terms of safety and positive diagnostic yield in 14 patients (93.3%),
and histopathalogical validity of results (93.3%). Only one patient suffered mild
neurological deficit (6.7%), one patient had inconclusive tissue diagnosis and invalid
result (6.7%). biopsy proven lesion was astrocytoma in 04 patients (26.7%), anaplastic
astrocytoma in 04 (26.7%), gliomatosis in 02 (13.3%), tuberculomas in 03 (20.0%),
metastatic adenocarcinomas in 01 (6.7%) and lymphoma in 01(6.7%). Conclusions: We
conclude that computerized stereotactic brain biopsy is safe and effective procedure with
a high diagnostic yield at our center.
Key words: Computerized stereotactic biopsy, brain, Brown-Roberts-Wells (BRW)

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