CORRELATION OF QUALITY OF LIFE IN PATIENTS OF CIRRHOSIS OF LIVER WITH ETIOLOGY AND DISEASE SEVERITY USING DISEASE-SPECIFIC QUALITY OF LIFE QUESTIONNAIRE

Bader Faiyaz Zuberi, Abdul Rauf Memon, Salahuddin Afsar, Rashid Qadeer, Rajesh Kumar

Abstract


Background: Quality of Life has an important status in patient management suffering from
chronic disease like cirrhosis and health related quality of life has significant impact on patient
management. This study was conducted to evaluate the correlation of health related quality of life
with disease severity in patients of cirrhosis of liver. Methods: This cross-sectional study was
conducted at Medical Unit -IV, Dow University of Health Sciences, Karachi, during the period
January 2006 to October 2006. All patients of cirrhosis of liver admitted during the study period
were selected. Patients with encephalopathy, hepatocellular carcinoma were excluded. The 29 item
chronic liver disease questionnaire (CLDQ) was administered to the patients by a postgraduate
trainee. Internal validity of responses was checked statistically and correlation of responses was
done with disease severity by Child-Pughs Criteria. Results: 109 patients were selected with 72
males and 37 females. Patient classification according to Child class A, B & C was 30, 38 & 41
respectively. The mean CLDQ score in the patients was 89.5 ±30.4. It correlated significantly with
Child Class but did not correlate with the gender, age and etiology of cirrhosis. Conclusion:
Health related CLDQ scores correlate with the severity of liver disease.
Keywords: Cirrhosis; Chronic liver disease; Quality of life; Health quality of life.related

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References


Addington-Hall J, Kalra L. Who should measure quality of

life? BMJ 2001; 322: 1417-20.

Chochinov HM, Tataryn D, Clinch JJ, Dudgeon D. Will to live

in the terminally ill. Lancet 1999; 354: 816-9.

El-Dika S, Guyatt GH, Armstrong D, Degl'innocenti A,

Wiklund I, Fallone CA, et al. The impact of illness in patients

with moderate to severe gastro-esophageal reflux disease.

BMC Gastroenterol 2005; 5: 23.

Kanwal F, Hays RD, Kilbourne AM, Dulai GS, Gralnek IM.

Are physician-derived disease severity indices associated with

health-related quality of life in patients with end-stage liver

disease? Am J Gastroenterol 2004; 99: 1726-32.

Gralnek IM, Hays RD, Kilbourne A, Rosen HR, Keeffe EB,

Artinian L, et al. Development and evaluation of the Liver

Disease Quality of Life instrument in persons with advanced,

chronic liver disease--the LDQOL 1.0. Am J Gastroenterol

; 95: 3552-65.

Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC,

Williams R. Transection of the oesophagus for bleeding

oesophageal varices. Br J Surg 1973; 60: 646-9.

D'Amico G, Garcia-Tsao G, Pagliaro L. Natural history and

prognostic indicators of survival in cirrhosis: a systematic

review of 118 studies. J Hepatol 2006; 44: 217-31.

Younossi ZM, Guyatt G, Kiwi M, Boparai N, King D.

Development of a disease specific questionnaire to measure

health related quality of life in patients with chronic liver

disease. Gut 1999; 45: 295-300.

SPSS [computer program]. version 15.0. Chicago: Statistical

Package for Social Sciences Inc.; 2006.

Cella DF, Tulsky DS. Measuring quality of life today:

methodological aspects. Oncology (Williston Park) 1990; 4:

-38; discussion 69.

Sumskiene J, Sumskas L, Petrauskas D, Kupcinskas L.

Disease-specific health-related quality of life and its

determinants in liver cirrhosis patients in Lithuania. World J

Gastroenterol 2006; 12: 7792-7.

Arguedas MR, DeLawrence TG, McGuire BM. Influence of

hepatic encephalopathy on health-related quality of life in

patients with cirrhosis. Dig Dis Sci 2003; 48:1622-6.

Younossi ZM, Boparai N, Price LL, Kiwi ML, McCormick M,

Guyatt G. Health-related quality of life in chronic liver disease:

the impact of type and severity of disease. Am J Gastroenterol

; 96: 2199-205.

Younossi ZM, Boparai N, McCormick M, Price LL, Guyatt G.

Assessment of utilities and health-related quality of life in

patients with chronic liver disease. Am J Gastroenterol 2001;

: 579-83.

Stanca CM, Bach N, Krause C, Tandon N, Freni MA,

Gutierrez JA, et al. Evaluation of fatigue in U.S. patients with

primary biliary cirrhosis. Am J Gastroenterol 2005;100:1104-9.

Hauser W, Holtmann G, Grandt D. Determinants of healthrelated quality of life in patients with chronic liver diseases.

Clin Gastroenterol Hepatol 2004; 2: 157-63.

Gallegos-Orozco JF, Fuentes AP, Gerardo Argueta J, PerezPruna C, Hinojosa-Becerril C, Sixtos-Alonso MS, et al. Healthrelated quality of life and depression in patients with chronic

hepatitis C. Arch Med Res 2003; 34: 124-9.

Heitkemper M, Jarrett M, Kurashige EM, Carithers R. Chronic

hepatitis C. Implications for health-related quality of life.

Gastroenterol Nurs 2001; 24: 169-75; quiz 76-7.

Dan AA, Martin LM, Crone C, Ong JP, Farmer DW, Wise T,

et al. Depression, anemia and health-related quality of life in

chronic hepatitis C. J Hepatol 2006; 44: 491-8.

Atiq M, Gill ML, Khokhar N. Quality of life assessment in

Pakistani patients with chronic liver disease. J Pak Med Assoc

; 54: 113-5.

Kim SH, Oh EG, Lee WH. Symptom experience,

psychological distress, and quality of life in Korean patients

with liver cirrhosis: a cross-sectional survey. Int J Nurs Stud

; 43: 1047-56.

Kalaitzakis E, Simren M, Olsson R, Henfridsson P, Hugosson

I, Bengtsson M, et al. Gastrointestinal symptoms in patients

with liver cirrhosis: associations with nutritional status and

J Ayub Med Coll Abbottabad 2007; 19(2)

health-related quality of life. Scand J Gastroenterol 2006; 41:

-72.

Girgrah N, Reid G, MacKenzie S, Wong F. Cirrhotic

cardiomyopathy: does it contribute to chronic fatigue and

decreased health-related quality of life in cirrhosis? Can J

Gastroenterol 2003; 17: 545-51.

Younossi ZM, Kiwi ML, Boparai N, Price LL, Guyatt G.

Cholestatic liver diseases and health-related quality of life. Am

J Gastroenterol 2000; 95: 497-502.

Rannard A, Buck D, Jones DE, James OF, Jacoby A. Assessing

quality of life in primary biliary cirrhosis. Clin Gastroenterol

Hepatol 2004; 2: 164-74.

Poupon RE, Chretien Y, Chazouilleres O, Poupon R, Chwalow

J. Quality of life in patients with primary biliary cirrhosis.

Hepatology 2004; 40: 489-94.

Dias Teixeira MC, de Fatima Gomes de Sa Ribeiro M, Strauss

E. A new insight into the differences among non-cirrhotic and

cirrhotic patients using the liver disease quality of life

instrument (LDQOL). Ann Hepatol 2005;4:264-71.


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