ANTIOXIDANT STATUS IN CORONARY HEART DISEASE (CHD) PATIENTS WITH TYPE 2 DIABETES MELLITUS

Bansilal Bansilal, Nasir Ali, Naeema Afzal, Taher Salim Khan, S. Shahjahan

Abstract


Background: The present study was carried out to see the levels of vitamin C, vitamin E and total
antioxidant (AO) in Coronary Heart Disease (CHD) patients with and without Type-2 Diabetes
Mellitus (T2DM). In various previous studies it has been reported that, diabetes, hypertension and
smoking are risk factors for CHD and all risk factors were common in these patients. Methods:
Serum was tested from 80 CHD patients and 21 healthy controls, matched for age, height, and
weight. Results: No significant difference was seen between the age, height and weight of the
subjects and controls. CHD patients were mostly male, smokers, over 40 year of age and belonging
upper class families. The mean plasma glucose was significantly higher (p<0.05) in CHD patients
having T2DM as compare to CHD patient with out T2DM. Risk factors for CHD, like diabetes,
hypertension and smoking were common in these patients. No significant difference was seen in
vitamin C level of patients of CHD. Vitamin E level was significantly (p<0.05) low among the CHD
patients as compared to controls and a significant (p<0.05) decrease in mean vitamin E level was
observed among smoker CHD patients as compared to non-smoker CHD patients. But no significant
difference in vitamin C and vitamin E levels of CHD patients with diabetes and hypertension were
observed when compared with CHD patients having no such complaints. The CHD patients’ total
antioxidant level was significantly (p<0.05) decreased as compared to controls. Conclusion: The
total AO (Vit. C and E) were not significantly higher in CHD patients with hypertension and diabetes
as compared to those patients of CHD having no hypertension and diabetes.
Keywords: Coronary Heart Disease (CHD), Ischemic Heart Disease (IHD). Type 2 Diabetes
Mellitus (T2DM), Fasting Plasma Glucose (FPG), Antioxidant (AO)

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