Ishma Aijazi, Monazza Chaudary, Sara Hussein Adam Mukhtar, Fadhil Mustafa Abdulla Al Shama


Malaria is a common public health problem which may have high morbidity and mortality.  Physicians should be aware of the unusual presentations of this disease so that it can be timely diagnosed and treated. Herein we are presenting a case of falciparum malaria who presented to the hospital with carpopedal spasm and tetany.  We will subsequently discuss mineral homeostasis and the mechanisms of hypocalcemia in falciparum malaria and the dysregulation of calcium, phosphorus and magnesium metabolism.

Full Text:



Irving KG, Kemp E, Olivier BJ, Mendelow BV. Unusual presentation of malaria as a leukaemoid reaction. A case report. S Afr Med J 1987;71(9):597–8.

Zaki SA, Shanbag P, Shenoy P. Unusual presentation of malaria as tetany: a case report. J Vector Borne Dis 2010;47(2):123–5.

Davis TM, Pukrittayakamee S, Woodhead JS, Holloway P, Chaivisuth B, White NJ. Calcium and phosphate metabolism in acute falciparum malaria. Clin Sci 1991;81(3):297–304.

Davis TM, Singh B, Choo KE, Ibrahim J, Sulaiman SA, Kadir ZA, et al. Dynamic assessment of parathyroid function in acute malaria. J Intern Med 1998;243(5):349–54.

Mishra S. Malaria-Precipitated Hypocalcaemia and related complications. Pharma Innov 2013;2(2, Part A):162–8.

Staines HM, Chang W, Ellory JC, Tiffert T, Kirk K, Lew V. Passive Ca2+ Transport and Ca2-dependent K+ transport in Plasmodium falciparum-infected red cells. J Membr Biol 1999;172(1):13–24.

Adini A, Krugliak M, Ginsburg H, Li L, Lavie L, Warburg A. Transglutaminase in Plasmodium parasites: activity and putative role in oocysts and blood stages. Mol Biochem Parasitol 2001;117(2):161–8.

Singh PS, Singh N. Tetany with Plasmodium falciparum infection. J Assoc Physicians India 2012;60:57–8.

Wilson M, Davis TM, Binh TQ, Long TT, Danh PT, Robertson K. Pituitary-adrenal function in uncomplicated falciparum malaria. Southeast Asian J Trop Med Public Health 2001;32(4):689–95.

Davis TM, Supanaranond W, Pukrittayakamee S, Krishna S, Hart GR, Burrin JM, et al. The pituitary-thyroid axis in severe falciparum malaria: evidence for depressed thyrotroph and thyroid gland function. Trans Royal Soc Trop Med Hyg 1990;84(3):330–5.

Prabha MR, Pereira P, Chowta N, Hegde BM. Clinical implications of hypocalcemia in malaria. Indian J Med Res 1998;108:62–5.


  • There are currently no refbacks.

Contact Number: +92-992-382571

email: [jamc] [@] [ayubmed.edu.pk]