QUALITY OF LIFE AND RELATIONSHIP BETWEEN FUNCTIONING AND SYMPTOMS OF FEMALE PATIENTS WITH BREAST CANCER BEFORE CHEMOTHERAPY IN A CANCER CLINIC AT YANGON, MYANMAR

Min Thu Naung, Alessio Panza

Abstract


Background: Better quality of life (QOL) is associated with longer survival in cancer patients. This study evaluated the QOL and relationship between functioning and symptoms among female breast cancer patients before chemotherapy. Methods: Cross-sectional study was conducted by including 74 participants attending a cancer clinic. European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(s)-Core30 was applied for assessing QOL. It was composed of three domains namely global health status/QOL, functioning (includes five categories) and symptoms (includes nine categories). Pearson correlation and multiple linear regression were performed to find the relationship between functioning and symptoms in participants. The study was approved by Institutional Review Board of Defence Services Medical Research Centre, Myanmar with approval number IRB/2018/34. Results: Global health status/QOL score was fair (61.8±20.1). Among the five categories of functioning, cognitive functioning score (83.6±19.8) was the highest and role functioning score (66.4±29.3) was the lowest. Among symptoms, insomnia score (29.3±30.7) was the highest and diarrhoea score (0.9±5.4) was the lowest. When Pearson correlation was performed, functioning and symptoms were negatively correlated. Fatigue had significant (p<0.001) moderate negative correlation with physical functioning, role functioning and emotional functioning, whereas pain with role functioning (p<0.001). When linear regression was performed, nausea & vomiting was the strongest predictor for impaired global health status/QOL (p<0.05), while fatigue was the strongest predictor for impairment in all five categories of functioning (p<0.05). Conclusion:  Functioning and symptoms were negatively correlated in breast cancer patients. Nausea & vomiting and fatigue were the strongest predictors for impaired QOL.

Keywords: Breast Cancer; Chemotherapy; Functioning; Symptoms; Quality of Life; QOL

Full Text:

PDF

References


WHO. Breast cancer: prevention and control. [Internet]. World Health Organization; [cited 2020 Jan]. Available from: https://www.who.int/cancer/detection/breastcancer/en/

IARC. Cancer Fact Sheets: Breast: International Agency for Research on Cancer; 2019. [Internet]. International Agency for Research on Cancer [cited 2010 Jan]. Available from: https://gco.iarc.fr/today/data/factsheets/cancers/20-Breast-fact-sheet.pdf

IARC. Population Fact Sheets: South-Eastern Asia: International Agency for Research on Cancer; 2019. [Internet]. International Agency for Research on Cancer [cited 2010 Jan]. Available from: https://gco.iarc.fr/today/data/factsheets/populations/920-south-eastern-asia-fact-sheets.pdf

IARC. Population Fact Sheets: Myanmar: International Agency for Research on Cancer; 2019. [Internet]. International Agency for Research on Cancer [cited 2010 Jan]. Available from: https://gco.iarc.fr/today/data/factsheets/populations/104-myanmar-fact-sheets.pdf

Chui PL, Abdullah KL, Wong LP, Taib NA. Quality of Life in CAM and Non-CAM Users among Breast Cancer Patients during Chemotherapy in Malaysia. PloS One 2015;10(10):e0139952.

Gangane N, Khairkar P, Hurtig AK, San Sebastian M. Quality of Life Determinants in Breast Cancer Patients in Central Rural India. Asian Pac J Cancer Prev 2017;18(12):3325–32.

Epplein M, Zheng Y, Zheng W, Chen Z, Gu K, Penson D, et al. Quality of life after breast cancer diagnosis and survival. J Clin Oncol 2011;29(4):406–12.

Quinten C, Coens C, Mauer M, Comte S, Sprangers MA, Cleeland C, et al. Baseline quality of life as a prognostic indicator of survival: a meta-analysis of individual patient data from EORTC clinical trials. Lancet Oncol 2009;10(9):865–71.

Hassen AM, Taye G, Gizaw M, Hussien FM. Quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia. PloS One 2019;14(9):e0222629.

Ho PJ, Gernaat SAM, Hartman M, Verkooijen HM. Health-related quality of life in Asian patients with breast cancer: a systematic review. BMJ Open 2018;8(4):e020512.

Arndt V, Stegmaier C, Ziegler H, Brenner H. A population-based study of the impact of specific symptoms on quality of life in women with breast cancer 1 year after diagnosis. Cancer 2006;107(10):2496–503.

Meneses K, Azuero A, Hassey L, McNees P, Pisu M. Does economic burden influence quality of life in breast cancer survivors? Gynecol Oncol 2012;124(3):437–43.

Alawadi SA, Ohaeri JU. Health - related quality of life of Kuwaiti women with breast cancer: a comparative study using the EORTC Quality of Life Questionnaire. BMC Cancer 2009;9(1):222.

Shafaie F, Mirghafourvand M, Amirzehni J. Predictors of quality of life in patients with breast cancer. Indian J Palliat Care 2019;25(1):73–8.

EORTC. Quality of Life of Cancer Patients. [Internet]. European Organisation for Research and Treatment of Cancer [cited 2020 Jan]. Available from: https://qol.eortc.org/questionnaire/eortc-qlq-c30/

Scott NW, Fayers P, Aaronson NK, Bottomley A, de Graeff A, Groenvold M, et al. EORTC QLQ-C30 Reference Values Manual. In Brussels, Belgium: EORTC Quality of Life Group, 2008; p. 427.

Htet K. Quality of life and its associate factors among breast cancer survivors at out-patient department of radiotherapy ward, Yangon General Hospital. Yangon, Myanmar: University of Public Health, Yangon, Myanmar; 2016. www.uph-myanmar.gov.mm/wp-content/uploads/abstracts/uphd254.pdf

El Fakir S, El Rhazi k, Zidouh A, Bennani M, Benider A, Errihani H, et al. Health-Related Quality of Life among Breast Cancer Patients and Influencing Factors in Morocco. Asian Pac J Cancer Preven 2016;17(12):5063–9.

Ram H, Da E-S, Nm A, Sa B. Quality of life and work limitation among survivors of breast cancer at zagazig university hospitals, egypt. Egypt J Occup Med 2018;42(2):195–208.

El Sharkawi FM. Effect of different modalities of treatment on the quality of life of breast cancer patients in Egypt. EMHJ-East Mediterr Health J 1997;3(1):68–81.

Safaee A, Moghimi-Dehkordi B, Zeighami B, Tabatabaee H, Pourhoseingholi M. Predictors of quality of life in breast cancer patients under chemotherapy. Indian J Cancer 2008;45(3):107–11.

Brezden CB, Phillips KA, Abdolell M, Bunston T, Tannock IF. Cognitive function in breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol 2000;18(14):2695–701.

Rahou BH, El Rhazi K, Ouasmani F, Nejjari C, Bekkali R, Montazeri A, et al. Quality of life in Arab women with breast cancer: a review of the literature. Health Qual Life Outcomes 2016;14:64.

Srimontayamas S, Sa-Nguanraksa D, Lohsiriwat V, Rushatamukayanunt P, Imruetaicharoenchoke W, Prasartong-Osoth P, et al. Quality of life in breast cancer survivors: Comparative study of mastectomy, mastectomy with immediate transverse rectus abdominis musculocutaneous flap reconstruction and breast conserving surgery. J Med Assoc Thailand 2017;100:S38–45.

Thanarpan P, Somrit M, Rungarun J, Paytai R, Duangjai S, Chanon K, et al. Cosmetic Outcomes and Quality of Life in Thai Women Post Breast Conserving Therapy for Breast Cancer. Asian Pac J Cancer Preven 2015;16(11):4685–90.

Pongthavornkamol K, Lekdamrongkul P, Pinsuntorn P, Molassiotis A. Physical Symptoms, Unmet Needs, and Quality of Life in Thai Cancer Survivors after the Completion of Primary Treatment. Asia Pac J Oncol Nurs 2019;6(4):363–71.

Imran M, Al-Wassia R, Alkhayyat SS, Baig M, Al-Saati BA. Assessment of quality of life (QoL) in breast cancer patients by using EORTC QLQ-C30 and BR-23 questionnaires: A tertiary care center survey in the western region of Saudi Arabia. PloS One 2019;14(7):e0219093.

Tehrani AM, Farajzadegan Z, Rajabi FM, Zamani AR. Belonging to a peer support group enhance the quality of life and adherence rate in patients affected by breast cancer: A non-randomized controlled clinical trial. Journal of research in medical sciences. J Res Med Sci 2011;16(5):658–65.

Ancoli-Israel S, Liu L, Marler MR, Parker BA, Jones V, Sadler GR, et al. Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer. Supportive care in cancer. Support Care Cancer 2006;14(3):201–9.

Bardwell WA, Ancoli-Israel S. Breast Cancer and Fatigue. Sleep Med Clin 2008;3(1):61–71.

Saleha B, Shakeel A, Shumaila E, Shazia R, Rashid R, Ibrahim M. An assessment of quality of life in breast cancer patients using EORTC QLQ C30/+BR23 questionnaire. Int J Cancer Manag 2010;3(2):e80684.

Separovic R, Silovski T, Tecic Vuger A, Bajic Z, Silovski H, Juric A. Association of Breast Cancer Symptoms with Patients' Quality of Life and Depression; A Croatian Cross-Sectional Study. Psychiatr Danub 2019;31(Suppl 1):92–8.


Refbacks

  • There are currently no refbacks.


Contact Number: +92-992-382571

email: [jamc] [@] [ayubmed.edu.pk]