ANTIOXIDANT EFFECT OF VITAMIN E ON CARBON TETRACHLORIDE INDUCED TUBULOINTERSTITIAL AND GLOMERULAR DAMAGE IN THE KIDNEYS OF ALBINO MICE

Authors

  • Shabnum Aamir KHYBER MEDICAL COLLEGE PESHAWAR
  • Zia ud Din Assistant Professor, Anatomy department, Khyber Medical College, Peshawar.
  • Zahid Sarfaraz Khan Assistant Professor, Anatomy department, Khyber Girls Medical College, Peshawar.
  • Humaira Imtiaz Assistant Professor, Anatomy department, Ayub Medical College, Abbott Abad.
  • Faheem ul Haq Assistant Professor, Urology department, Ayub Medical Complex, Abbott Abad.
  • Hajira Ishaq Assistant Professor, Biochemistry department, Khyber Medical College, Peshawar.

Abstract

Background: Chemical induced nephrotoxicity is one of the main causes of acute kidney injury. The objective of this study was to determine the antioxidant effect of vitamin E against carbon tetrachloride induced tubulointerstitial and glomerular damage in the kidney of albino mice. Methods: The study had been conducted on albino mice. The duration of study was for five weeks. A total of 35 animals were randomly divided into five groups A, B, C, D and E .The group A served as control group, group B was administered only with carbon tetrachloride (no vitamin E) and groups C, D and E  received test drug (vitamin E) in doses of 1, 10 and 50mg/kg body weight respectively along with  CCl4. The animals were dissected and kidneys were excised for microscopic study for possible histo-morphological effects. Results: It was observed that carbon tetrachloride treated experimental groups developed tubulo-interstitial and glomerular changes as compared to control group A. The results suggested that these changes were significantly reduced in vitamin E treated groups especially in dose of 50 mg/kg body weight. Conclusion: This study reveals that tubulo-interstitial and glomerular damage caused by carbon tetrachloride can be reduced by vitamin E in dose of 50 mg/kg body weight.Keywords: Vitamin E; Carbon tetrachloride and Glomerular damage

Author Biographies

Shabnum Aamir, KHYBER MEDICAL COLLEGE PESHAWAR

Assistant Professor, Anatomy deptartment,Khyber Medical College ,Peshawar

Zia ud Din, Assistant Professor, Anatomy department, Khyber Medical College, Peshawar.

Assistant Professor, Anatomy department, Khyber Medical College, Peshawar.

Zahid Sarfaraz Khan, Assistant Professor, Anatomy department, Khyber Girls Medical College, Peshawar.

Assistant Professor, Anatomy department, Khyber Girls Medical College, Peshawar.

Humaira Imtiaz, Assistant Professor, Anatomy department, Ayub Medical College, Abbott Abad.

Assistant Professor, Anatomy department, Ayub Medical College, Abbott Abad.

Faheem ul Haq, Assistant Professor, Urology department, Ayub Medical Complex, Abbott Abad.

Assistant Professor, Urology department, Ayub Medical Complex, Abbott Abad.

Hajira Ishaq, Assistant Professor, Biochemistry department, Khyber Medical College, Peshawar.

Assistant Professor, Biochemistry department, Khyber Medical College, Peshawar.

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Published

2020-06-28

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