USING THYPRO 39 SCALE FOR PREDICTING THE QUALITY OF LIFE IN HYPOTHYROID PATIENTS AT LADY READING HOSPITAL.
Abstract
ABSTRACT: Background: Thyroid disorders are the second most common endocrine diseases. With regards to Hypothyroidism, it has a slow indolent course over the years, before its diagnosis. Most of the patient, on adequate treatment with biochemical euthyroid status, have generalised symptoms that affect their quality of life. Several tools to assess quality of life in thyroid disorders have been validated and recommended for use for those patients in clinical follow ups. ThyPRO 39 is one of a recently developed thyroid-specific quality of life (QoL) questionnaire applicable to patients with benign thyroid disorders (BTD). Purpose:The purpose of this study was to predict the thyroid-related quality of life (QoL) instrument ThyPRO 39 in patients with Hypothyroidism, who were rendered euthyroid with thyroid replacement therapy prior to the administration of study tool and to assess the internal reliability of this scale in our population. Methods: A sample of 52 patients undergoing maintenance treatment for Hypothyroidism who visited the outpatient Endocrinology clinics at Lady Reading Hospital was included. They were interviewed for their baseline demographic details and details on ThyPRO 39 questionnaire were recorded after a written informed consent. The data was entered and analysed on SPSS 25. The Internal reliability of the ThyPRO 39 scale was assessed for multi-item scales using Cronbach’s alpha coefficient. Results: The ThyPRO 39 scale demonstrated good responsiveness across the whole range of QoL aspects in patients with hypothyroidism. Internal reliability for ThyPRO 39 scale was satisfactory. Cronbach’s Alpha in our study was 0.928, which was comparable to the results of other studies. Conclusions: We suggest implementing this measurement tool as a patient-reported outcome in clinical studies in our indigenous population and further more to utilise it as a screening tool for QoL in clinical management of Hypothyroidism in our routine medical consultations. Key words: thyroid disease, hypothyroidism, quality of life, ThyPRO 39 questionnaire.References
Bianchi GP, Zaccheroni V, Solaroli E, Vescini F, Cerutti R, Zoli M, et al. Health-related quality of life in patients with thyroid disorders. Qual Life Res 2004;13(1):45–54.
McMillan C, Bradley C, Razvi S, Weaver J. Evaluation of New Measures of the Impact of Hypothyroidism on Quality of Life and Symptoms: The ThyDQoL and ThySRQ. Value Health 2008;11(2):285–94.
McMillan C, Bradley C, Woodcock A, Razvi S, Weaver J. Design of New Questionnaires to Measure Quality of Life and Treatment Satisfaction in Hypothyroidism. Thyroid 2004;14(11):916–25.
Kelderman-Bolk N, Visser T, Tijssen J, Berghout A. Quality of life in patients with primary hypothyroidism related to BMI. Eur J Endocrinol 2015;173(4):507–15.
Winther K, Cramon P, Watt T, Bjorner J, Ekholm O, Feldt-Rasmussen U, et al. Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy. PLoS One 2016;11(6):e0156925.
Watt T, Hegedüs L, Groenvold M, Bjorner JB, Rasmussen AK, Bonnema SJ, et al. Validity and reliability of the novel thyroid-specific quality of life questionnaire, ThyPRO. Eur J Endocrinol 2010;162(1):161–7.
Watt T, Bjorner J, Groenvold M, Cramon P, Winther K, Hegedüs L, et al. Development of a Short Version of the Thyroid-Related Patient-Reported Outcome ThyPRO. Thyroid 2015;25(10):1069–79.
Watt T, Bjorner JB, Groenvold M, Rasmussen AK, Bonnema SJ, Hegedus L, et al. Establishing construct validity for the thyroid-specific patient reported outcome measure (ThyPRO): an initial examination. Qual Life Res 2009;18(4):483–96.
Watt T, Cramon P, Hegedus L, Bjorner JB, Bonnema SJ, Rasmussen AR, et al. The thyroid-related quality of life measure ThyPRO has good responsiveness and ability to detect relevant treatment effects. J Clin Endocrinol Metab 2014;99:3708–17. pmid:25004246
Neslihan Ilkaz RN, Emine Iyigun RN, Ozturk E, Aydogdu A, Gorgulu S. The Turkish Version of the Thyroid-Specific Quality of Life Questionnaire, ThyPRO: A Validity and Reliability Study. Int J Caring Sci 2018;11(2):800–11.
Bukvic B, Zivaljevic V, Sipetic S, Diklic A, Tausanovic K, Paunovic I. Validation and cross-cultural adaptation of the questionnaire ThyPRO in thyroid patients in Serbia. Vojnosanit Pregl 2015;72(7):583–8.
Zahan AE, Watt T, Pascanu I, Rasmussen AK, Hegedus L, Bonnema SJ, et al. The Romanian version of the thyroid-related patient-reported outcomes ThyPRO and ThyPRO-39. Translation and assessment of reliability and cross-cultural validity. Acta Endocrinol (Buchar) 2018;14(2):192–200.
Wong CKH, Choi EPH, Woo YC, Lang BH. Measurement properties of thypro short-form (thypro-39) for use in chinese patients with benign thyroid diseases. Qual Life Res 2018;27(8):2177–87.
Mintziori G, Watt T, Veneti S, Panagiotou A, Pournaras DJ, Feldt-Rasmussen U, et al. ThyPROgr: the Greek edition of the ThyPRO questionnaires for patients with benign thyroid diseases. Hormones (Athens) 2018;17(1):107–12.
Published
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
