A Rare Case of Severe Acrodermatitis Enteropathica During Covid-19 Lockdown.

Authors

  • Taimoor Hussain Bolan Medical Complex Hospital Quetta
  • Jasvindar Kumar Khyber teaching Hospital Peshawar
  • Taimur Aslam Lady reading Hospital Peshawar
  • Saad Khan Khyber teaching Hospital Peshawar
  • Muhammad Ishaq Khyber teaching Hospital Peshawar
  • Daneet Kumar Hayatabad Medical Complex Peshawar.

DOI:

https://doi.org/10.55519/JAMC-04-10371

Keywords:

Acrodermatitis enteropathica, Pakistan, Covid-19 Lockdown, Treatment non compliance

Abstract

Acrodermatitis Enteropathica is a rare hereditary condition characterized by perioral dermatitis, diarrhea, and alopecia. Etiology includes autosomal recessive inheritance and acquired causes such as protein malnutrition, malabsorption syndromes, premature births, parenteral nutrition, chronic illnesses, and alcoholism. We report a case of a 12-year old boy who presented with cutaneous manifestations involving the whole body, diarrhea, and sparse hairs. A low level of plasma zinc, and alkaline phosphatase level was revealed and he was started on zinc supplements. He significantly improved in a few days, and was discharged after counseling the parents about treatment compliance.  This case highlights importance of early diagnosis, and the importance of treatment compliance in Acrodermatitis Enteropathica. It also stresses the need to take measures to ensure the continuity of health dissemination especially in remote areas.

References

Schmitt S, Küry S, Giraud M, Dréno B, Kharfi M, Bézieau S. An update on mutations of the SLC39A4 gene in acrodermatitis enteropathica. Hum Mutat 2009;30(6):926-33.

Nistor N, Ciontu L, Frasinariu OE, Lupu VV, Ignat A, Streanga V. Acrodermatitis enteropathica: a case report. Medicine (Baltimore) 2016;95(20):e3553.

Kaur S, Thami GP, Kanwar AJ. Acrodermatitis enteropathica in a full-term breast-fed infant. Indian J Pediatr 2002;69(7):631-3.

Maverakis E, Fung MA, Lynch PJ, Draznin M, Michael DJ, Ruben B, et al. Acrodermatitis enteropathica and an overview of zinc metabolism. J Am Acad Dermatol 2007;56(1):116-24.

Wang K, Pugh EW, Griffen S, Doheny KF, Mostafa WZ, al-Aboosi MM, et al. Homozygosity mapping places the acrodermatitis enteropathica gene on chromosomal region 8q24.3. Am J Hum Genet 2001;68(4):1055-60.

Wang F, Kim BE, Dufner-Beattie J, Petris MJ, Andrews G, Eide DJ. Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter. Hum Mol Genet 2004;13(5):563-71.

Perafán-Riveros C, França LF, Alves AC, Sanches Jr JA. Acrodermatitis enteropathica: case report and review of the literature. Pediatr Dermatol 2002;19(5):426-31.

Prasad AS. Clinical manifestations of zinc deficiency. Annu Rev Nutr 1985;5(1):341-63.

Dev T, Sethuraman G. Diagnosis of acrodermatitis enteropathica in resource limited settings. BMJ Case Rep 2017;2017:bcr2017220928.

Jensen SL, McCuaig C, Zembowicz A, Hurt MA. Bullous lesions in acrodermatitis enteropathica delaying diagnosis of zinc deficiency: a report of two cases and review of the literature. J Cutan Pathol 2008;35(Suppl 1):1-3.

Ciampo IR, Sawamura R, Ciampo LA, Fernandes MI. Acrodermatitis enteropathica: Clinical manifestations and pediatric diagnosis. Rev Paul Pediatr 2018;36(2):238-41.

Oleske JM, Westphal ML, Shore S, Gorden D, Bogden JD, Nahmias A. Zinc therapy of depressed cellular immunity in acrodermatitis enteropathica: its correction. Am J Dis Child 1979;133(9):915-8.

Downloads

Published

2022-09-28

How to Cite

Hussain, T., Kumar, J., Aslam, T., Khan, S., Ishaq, M. ., & Kumar, D. (2022). A Rare Case of Severe Acrodermatitis Enteropathica During Covid-19 Lockdown. Journal of Ayub Medical College Abbottabad, 34(4), 880–882. https://doi.org/10.55519/JAMC-04-10371

Issue

Vol. 34 No. 4 (2022): JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD

Section

CASE REPORT

License

Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License  CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.

USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.

AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.