SIMPLE MICRONEEDLING VERSUS MICRONEEDLING WITH TOPICAL INSULIN IN THE TREATMENT OF POST ACNE ATROPHIC SCARS; A SPLIT FACE COMPARATIVE STUDY
DOI:
https://doi.org/10.55519/JAMC-04-12893Keywords:
Acne vulgaris, Post acne scars, insulin, microneedling, adolescenceAbstract
Background: Acne vulgaris is a common skin condition, involving upto 90% of the teenage population, being more common in women than in men. Post acne scars are the sequelae, leading to low esteem and self confidence in the affected individuals. Methods: Thirty patients participated in the study. On each patient, over the left side of the face, microneedling was done using topical insulin as a medium, while on the right side of the face, simple microneedling was done. Four such sessions, a month apart, were done in all the patients. They were called for follow up and the response was based on the "Acne scar assessment scale", in which Grade-0 referred to no improvement, Grade-1 referred to an improvement of less than 25%, Grade-2 was an improvement between 25–50%, Grade-3 meant an improvement between 50–75%, and, Grade-4 referred to an improvement of greater than 75%. Results: After completion of the sessions, over the left side of the face, where microneedling was done with insulin 11 (36.7%) patients showed Grade-2 improvement, while 19 (63.3%) patients showed Grade-3 improvement. On the right side of the face where simple microneedling was done, 10 (33.3%) patients showed an improvement of Grade-0, and 20 (66.6%) patients showed an improvement of Grade-1. Conclusion: After this study, we conclude that microneedling combined with topical insulin, shows better results in patients with scarring. It can be a breakthrough in the treatment of post acne scars, due to easier availability and lesser cost of insulin.
References
1. Khakimova L, Abdukhamidova D, Akhmedova M, Ablaku-lova M. Acne in Allergic Skin Diseases. Tex J Med Sci 2022;8:129–31.
2. Heng AH, Chew FT. Systematic review of the epidemiology of acne vulgaris. Sci Rep 2020;10(1):5754.
3. Poli F, Dreno B, Verschoore M. An epidemiological study of acne in female adults: Results of a survey conducted in France. J Eur Acad Dermatol Venereol 2001;15(6):541–5.
4. Shah N, Shukla R, Chaudhari P, Patil S, Patil A, Nadkarni N, et al. Prevalence of acne vulgaris and its clinico‐epidemiological pattern in adult patients: Results of a pro-spective, observational study. J Cosmet Dermatol 2021;20(11):3672–8.
5. Chilicka K, Rusztowicz M, Szyguła R, Nowicka D. Methods for the improvement of acne scars used in dermatology and cosmetology: a review. J Clin Med 2022;11(10):2744.
6. Ogé LK, Broussard A, Marshall MD. Acne vulgaris: diagno-sis and treatment. Am Fam Physician 2019;100(8):475–84.
7. Cong TX, Hao D, Wen X, Li XH, He G, Jiang X. From patho-genesis of acne vulgaris to anti-acne agents. Arch Dermatol Res 2019;311(5):337–49.
8. Zhang JZ, Xiang F, Yu SR, Luo D, Li TT, Kang XJ. Associa-tion between acne and smoking: systematic review and meta-analysis of observational studies. Chin Med J 2021;134(15):1887–8.
9. Monib KM, Salem RM, Alfallah AA, EL-Sayed SE. Risk Factors for Acne Vulgaris Development. Benha J Appl Sci 2020;5(5 part 2):283–7.
10. Stamu‐O'Brien C, Jafferany M, Carniciu S, Abdelmaksoud A. Psychodermatology of acne: psychological aspects and ef-fects of acne vulgaris. J Cosmet Dermatol 2021;20(4):1080–3.
11. Szepietowska M, Dąbrowska A, Nowak B, Skinderowicz K, Wilczyński B, Krajewski PK, et al. Facial acne causes stig-matization among adolescents: A cross‐sectional study. J Cosmet Dermatol 2022;21(12):6815–21.
12. Sitohang IB, Sirait SA, Suryanegara J. Microneedling in the treatment of atrophic scars: A systematic review of random-ised controlled trials. Int Wound J 2021;18(5):577–85.
13. Gupta A, Kaur M, Patra S, Khunger N, Gupta S. Evidence-based surgical management of post-acne scarring in skin of color. J Cutan Aesthet Surg 2020;13(2):124–41.
14. Arsiwala NZ, Inamadar AC, Adya KA. A comparative study to assess the efficacy of fractional carbon dioxide laser and combination of fractional carbon dioxide laser with topical autologous platelet-rich plasma in post-acne atrophic scars. J Cutan Aesthet Surg 2020;13(1):11–7.
15. Chang HC, Sung CW, Lin MH. Combination therapy with microneedling and platelet-rich plasma for acne scarring: a systematic review and meta-analysis. Dermatol Surg 2020;46(8):1118–2216.
16. Wang J, Xu J. Effects of topical insulin on wound healing: a review of animal and human evidences. Diabetes Metab Syndr Obes 2020;13:719–27.
17. Chang HJ, Huang K, Wu C. "Determination of Sample Size in Using Central Limit Theorem for Weibull Distribution." Int J Inf Manag Sci 2006;17(3):153–74.
18. Khalid FA, Ahmad S, Mehrose MY, Saleem M, Yousaf MA, Mujahid AM, et al. Efficacy of micro-needling on post acne scars. J Ayub Med Coll Abbottabad 2019;31(3):336–9.
19. Goodarzi A, Behrangi E, Ghassemi M, Nobari NN, Sadeghzadeh-Bazargan A, Roohaninasab M. Acne scar; a re-view of classification and treatment. J Crit Rev 2020;7(5):815–23.
20. Pawar M, Singh M. Microneedling with autologous platelet-rich plasma versus microneedling with topical insulin in the treatment of postacne atrophic scars: a simultaneous split-face comparative study. J Am Acad Dermatol 2021;84(3):810–1.
21. Abbas MA, Elgamal EE, Zaky MS, Elsaie ML. Micronee-dling with topical vitamin C versus microneedling with top-ical insulin in the treatment of atrophic post‐acne scars: A split‐face study. Dermatol Ther 2022;35(5):e15376.
22. Dogra S, Yadav S, Sarangal R. Microneedling for acne scars in Asian skin type: an effective low cost treatment modality. J Cosmet Dermatol 2014;13(3):180–7.
23. Memon Q, Rasheed S, Hafeez A, Abbas Z. The Comparison of Treatment Efficacy and Outcomes of Microneedling and Glycolic Acid Peels
24. for Acne Scar. Pak J Med Health Sci 2022;16(11):390–2.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Mira Ali, Najia Ahmed, Seemab Khan, Afshan kiran

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.