PAEDIATRIC HEPATIC HAEMANGIOMA-A RARE CAUSE OF PYREXIA OF UNKNOWN ORIGIN
DOI:
https://doi.org/10.55519/JAMC-04-12918Keywords:
Pyrexia of unknown origin; Hepatic Haemangioma; Bleeding haemangiomaAbstract
Pyrexia of unknown origin (PUO) has remained a diagnostic challenge for medical professionals for decades as its aetiology remains elusive and requires extensive investigation. Hepatic Haemangioma (HH) is generally not considered a possible cause of PUO. HH is the most frequent, non-cancerous tumor in children usually presents as vague abdominal pain. We describe a case of 4-year-old female presented with the complaint of dull abdominal pain associated with low grade fever. Extensive workup was done to find out the cause. Her haemoglobin also dropped suggestive of bleeding haemangioma. She was treated with steroids (prednisolone) which significantly reduced her inflammatory markers prior to surgery. Later, hepatectomy was done. The surgery was uneventful, and her PUO was also resolved.
References
1. Petersdorf RG, Beeson PB. Fever of unexplained origin: report on 100 cases. Medicine (Baltimore) 1961;40(1):1–30.
2. Rigante D, Esposito S. A roadmap for fever of unknown origin in children. Int J Immunopathol Pharmacol 2013;26(2):315–26.
3. Durack DT, Street AC. Fever of unknown origin-reexamined and redefined. Curr Clin Top Infect Dis 1991;11:35–51.
4. Knockaert DC, Vanderschueren S, Blockmans D. Fever of unknown origin in adults: 40 years on. J Intern Med 2003;253(3):263–75.
5. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines on the management of benign liver tumours. J Hepatol 2016;65(2):386–98.
6. Toro A, Mahfouz AE, Ardiri A, Malaguarnera M, Malaguarnera G, Loria F, et al. What is changing in indications and treatment of hepatic hemangiomas. A review. Ann Hepatol 2014;13(4):327–39.
7. Montero L, Canchari PG, Peña AL, Guerra EG. Review article: A giant hepatic hemangiomas. Gastroenterol Hepatol (Bartlesville) 2017;7(5):00251.
8. Hopkins K, Bailey RJ. Hepatic hemangioma: An unusual cause of fever of unknown origin. Can J Gastroenterol Hepatol 1990;4(6):227–9.
9. Hall GW. Kasabach-Merritt syndrome: pathogenesis and management: Review. Br J Haematol 2001;112(4):851–62.
10. Zarem HA, Edgerton MT. Induced resolution of cavernous hemangiomas following prednisolone therapy. Plast Reconstr Surg 1973;51(2):207.
11. Aspray M. Calcified hemangiomas of the liver. Am J Roentgenol 1945;53:446–53.
12. Plachta A. The triad syndrome inherent to calcified cavernous hemangioma of the liver. Angiology 1965;16(10):594–9.
13. Chowers I, Conforti N, Feldman S. Local effects of cortisone in the preoptic area in temperature regulation. Am J Physiol 1968;214:538–42.
14. Dillard GM, Bodel P. Studies of steroid fever-II. Pyrogenic and antipyrogenic activities in vitro of some endogenous steroids in man. J Clin Invest 1970;49:2418–26.
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