EARLY OUTCOMES OF WILMS TUMOR SURGERY IN CHILDREN TREATED WITH PRE-OPERATIVE CHEMOTHERAPY: AN EXPERIENCE FROM CANCER DEDICATED CENTER

Authors

  • Sajid Ali Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore-Pakistan https://orcid.org/0000-0002-1477-6876
  • Talha Javed Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore-Pakistan
  • Areej Muhammad Salim Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore-Pakistan
  • Tariq Latif Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore-Pakistan
  • Muhammad Ali Sheikh Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore-Pakistan

DOI:

https://doi.org/10.55519/JAMC-01-13062

Keywords:

Wilms Tumour; Children; Pre-operative chemotherapy; Nephrectomy

Abstract

Background: In recent times’ advances in surgical technique and chemotherapy resulted survival rate in Wilms tumour patients approaching 90%. Therefore, the study aimed to assess the efficacy of preoperative chemotherapy and to document the early postoperative surgical and oncological outcomes. Methods: The patients with Wilms tumour were reviewed who underwent radical nephrectomy from April 2020 to May 2023. Factors related to demographics, radiological findings, treatment provided, response to chemotherapy, and short-term outcomes were assessed. Mean and standard deviations were used to describe categorical data while frequencies and proportions were used to describe quantitative data. Results: Ninety patients with Wilms tumour received pre-operative chemotherapy and underwent radical nephrectomy with a mean age of 3.35±2.20 years. The majority of the patients presented within three months of the onset of the symptoms (81.0%) and the common symptom was abdominal mass (77.7%). Most of the patients were lying in the intermediate-risk stratification group (70.0%). The mean operative time was 2.02±0.75 hours. The mean high dependency unit (HDU) stay was 1.57±1.31 days and the mean hospital stay was 3.47±1.14 days. Furthermore, surgical complications were reported in nine (10%) patient, and four patients had early relapse, and two expired. There was a statistically significant chemotherapy response in terms of tumour size (pre-chemotherapy 9.6±3.29 cm versus post-chemotherapy tumour size 7.1±2.8 cm). Conclusions: Despite the delayed presentation and large volume of tumours, the initial results are favourable. Additionally, preoperative chemotherapy has played a crucial role in reducing tumour size and enabling successful surgical removal.

Author Biography

Sajid Ali, Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore-Pakistan

Correspondence:

Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Center

7A Block R-3 M.A. Johar Town, Lahore-Pakistan

Cell: +92 333 703 6440

Email: dr.sajidali@yahoo.com

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Published

2025-03-15

How to Cite

1.
Ali S, Javed T, Salim AM, Latif T, Sheikh MA. EARLY OUTCOMES OF WILMS TUMOR SURGERY IN CHILDREN TREATED WITH PRE-OPERATIVE CHEMOTHERAPY: AN EXPERIENCE FROM CANCER DEDICATED CENTER. J Ayub Med Coll Abbottabad [Internet]. 2025 Mar. 15 [cited 2025 Aug. 7];37(1):69-72. Available from: https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/13062