A A CASE OF CENTRAL NERVOUS SYSTEM INVASIVE ASPERGILLOSIS MIMICKING ORBITAL CELLULITIS IN A PATIENT WITH UNCONTROLLED TYPE 2 DIABETES MELLITUS AND END-STAGE RENAL DISEASE

Authors

  • Zomer Sardar Shalamar Medical and Dental College, Lahore
  • Azhar Nasim Services Hospital, Services Institute of Medical Sciences, Lahore
  • Mohammad Faisal Shalamar Medical and Dental College, Shalamar Hospital, Lahore
  • Mariam Danish Iqbal Shalamar Medical and Dental College, Shalamar Hospital, Lahore

Abstract

Central nervous system aspergillosis is a rare and often fatal complication seen in immunocompromised individuals. Here, we present the case of a 60-year-old female with uncontrolled type 2 diabetes mellitus and end-stage renal disease (ESRD) who was ultimately diagnosed with CNS aspergillosis. This case underscores the diagnostic challenge and delays posed by fungal infections in patients with predisposing conditions, necessitating a multidisciplinary approach for timely diagnosis and management.

References

1. Sharma RR, Pawar SJ, Lad SD, Mishra GP, Netalkar AS, Rege S. Fungal infections of the central nervous system. In: Quiñones-Hinojosa A, editor. Schmidek and Sweet Operative Neurosurgical Techniques. 6th ed. Philadelphia: W.B. Saunders: 2012; p.1691–732.

2. Patiroglu T, Unal E, Karakukcu M, Ozdemir MA, Tucer B, Yikilmaz A, et al. Multiple fungal brain abscesses in a child with acute lymphoblastic leukemia. Mycopathologia 2012;174(6):505–9.

3. Hamill RJ. Fungal infections of the central nervous system. In: Anaissie EJ, McGinnis MR, Pfaller MA, editors. Clinical Mycology. 2nd ed. Edinburgh: Churchill Livingstone: 2009; p.591–607.

4. Candoni A, Klimko N, Busca A, Cesaro S, Caira M, Garcia-Vidal C, et al. Fungal infections of the central nervous system and paranasal sinuses in onco-haematologic patients: epidemiological study reporting the diagnostic-therapeutic approach and outcome in 89 cases. Mycoses 2019;62(3):252–60.

5. Pasqualotto AC, Denning DW. Post-operative aspergillosis. Clin Microbiol Infect 2006;12(10):1060–76.

6. Miceli MH. Central nervous system infections due to Aspergillus and other hyaline molds. J Fungi (Basel) 2019;5(3):E65.

7. Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis DP, Marr KA, et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 2008;46(3):327–60.

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Published

2026-01-14

How to Cite

1.
Sardar Z, Nasim A, Mohammad Faisal, Danish Iqbal M. A A CASE OF CENTRAL NERVOUS SYSTEM INVASIVE ASPERGILLOSIS MIMICKING ORBITAL CELLULITIS IN A PATIENT WITH UNCONTROLLED TYPE 2 DIABETES MELLITUS AND END-STAGE RENAL DISEASE. J Ayub Med Coll Abbottabad [Internet]. 2026 Jan. 14 [cited 2026 Jan. 19];37(3):390-3. Available from: https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/13913