COMPARATIVE ANALYSIS OF SERUM CALCIUM LEVEL IN NORMOTENSIVE SINGLETON VERSUS PRE-ECLAMPTIC PREGNANCIES
DOI:
https://doi.org/10.55519/JAMC-02-14594Keywords:
Preeclampsia, Blood Calcium, Low Calcium, Pregnancy, Women’s Health, High Blood Pressure in PregnancyAbstract
Background: Preeclampsia is a complex condition during pregnancy that poses serious risks to both the mother and child, particularly in less developed regions. The relationship between blood calcium levels and preeclampsia remains poorly understood. This study investigates the potential association between blood calcium levels and the etiology of preeclampsia in pregnant Pakistani women. Methods: This study was conducted at the Obstetrics and Gynecology Departments of Pakistan Air Force Hospital, Kamra, and Pakistan Air Force Hospital, Islamabad, from December 2023 to May 2024. It included 107 women diagnosed with preeclampsia and 105 normotensive pregnant women, matched for age and parity. Data were collected through structured questionnaires, clinical examinations, and blood tests for calcium levels, analyzed using spectrophotometry. Statistical analysis was performed using SPSS version 23, with significance set at p<0.05. Results: Women with preeclampsia had significantly lower mean blood calcium levels (1.83±0.51 mmol/L) compared to the control group (2.22±0.12 mmol/L; p<0.01). They also exhibited higher body mass index, systolic blood pressure, and diastolic blood pressure. Hypocalcemia was observed in 41.12% of preeclamptic women versus 6.67% of controls (p=0.01). Conclusion: Blood calcium levels may serve as a potential indicator of preeclampsia. Regular monitoring of calcium levels could aid in predicting the onset and severity of the condition. Early identification and management of hypocalcemia may benefit pregnant women at risk of developing hypertension
References
1. Koley A, Das S, Sarkar S, Char D, Saha TK. Association of serum calcium and uric acid level with hypertensive disorders of pregnancy (preeclampsia and eclampsia) and their correlation with disease severity. IOSR J Dent Med Sci. 2013;9(5):32–5.
2. Purohit A, Vyas RK, Sharma ML, Soni Y, Verma A, Dadheech G. Alteration in serum calcium level in preeclampsia compared to normal pregnancy. Int J Clin Biochem Res. 2015;2(4):242–5.
3. Villar J, Betran AP, Gulmezoglu M. Epidemiological basis for the planning of maternal health services. London: WHO/RHR; 2001.
4. Adewolu OF. Serum sodium, potassium, calcium and magnesium in women with pregnancy-induced hypertension and preeclampsia in Oredo local government, Benin metropolis: A pilot study. Afr J Med Health Sci. 2013;12:1–5.
5. Ugwuja EI, Famurewa AC, Ikaraoha CI. Comparison of serum calcium and magnesium between preeclamptic and normotensive pregnant Nigerian women in Abakaliki, Nigeria. Ann Med Health Sci Res. 2016;6(1):33–7.
6. Jarjou LM, Prentice A, Sawo Y. Randomized, placebo-controlled, calcium supplementation study in pregnant Gambian women: effects on breast-milk calcium concentrations and infant birth weight, growth, and bone mineral accretion in the first year of life. Am J Clin Nutr. 2006;83(3):657–66.
7. Beinder E. Calcium supplementation in pregnancy—is it a must? Ther Umsch. 2007;64:243–7.
8. Punthumapol C, Kittichotpanich B. Serum calcium, magnesium and uric acid in preeclampsia and normal pregnancy. J Med Assoc Thai. 2008;91:968–73.
9. Cunningham FG. Hypertensive disorder in pregnancy. In: Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstre PL, Wenstrom KD, editors. Williams Obstetrics. 22nd ed. New York: McGraw-Hill; 2005. p. 761–808.
10. Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet. 2001;357:53–6.
11. Chaurasia PP, Jadav PA, Jasani JH. Changes in serum calcium and serum magnesium level in preeclampsia vs normal pregnancy. Int J Biomed Adv Res. 2012;3:511–3.
12. Sejovia B, Veja I, Villarreal E, Licona NA. Hypocalciuria during pregnancy as a risk factor of pre-eclampsia. Ginecol Obstet Mex. 2004;72:570–4.
13. Elawad T, Scott G, Bone JN. Risk factors for pre-eclampsia in clinical practice guidelines: comparison with the evidence. BJOG. 2022.
14. Kumru S, Aydin S, Simsek M, Sahin K. Comparison of serum copper, zinc, calcium and magnesium levels in preeclamptic and healthy pregnant women. Biol Trace Elem Res. 2003;94:105–12.
15. Duvekot EJ, De Groot C, Bloema-Kamp K, Oei S. Pregnant women with low milk intake have an increased risk of developing pre-eclampsia. Eur J Obstet Gynecol Reprod Biol. 2002;105:11–4.
16. Ritchie LD, King JC. Dietary calcium and pregnancy-induced hypertension. Is there a relation? Am J Clin Nutr. 2000;71:1371.
17. Agu CT, Okeudo C. A comparative study of serum calcium levels between pre-eclamptic and normotensive singleton pregnancies in Federal Medical Centre, Owerri. J Adv Med Med Res. 2018;27(11):1–8.
18. Magee L, Helewa M, Montquin J, Dadelszen P. Diagnosis, evaluation and management of the hypertensive disorders of pregnancy. J Obstet Gynaecol Can. 2008;206:17.
19. Shenqi W, Xulong H, Yu L, Huijuan L, Li W, Yugian B, et al. Serum electrolyte levels in relation to macrovascular complication in Chinese patients with diabetes mellitus. Cardiovasc Diabetol. 2013;12:146.
20. Ugwuja EI, Famurewa AC, Ikaraoha CI. Comparison of serum calcium and magnesium between preeclamptic and normotensive pregnant Nigerian women in Abakaliki, Nigeria. Ann Med Health Sci Res. 2016;6:33–7.
21. Owusu Darkwa E, Antwi-Boasiako C, Djagbletey R, Owoo C, Obed S, Sottie D. Serum magnesium and calcium in preeclampsia: a comparative study at the Korle-Bu Teaching Hospital, Ghana. Integr Blood Press Control. 2017;10:9–15.
22. Guhan VN, Jeyakumar M, Prabhakara RK, Daniel M, Sivaa R, Priyadharshini S. Serum calcium and magnesium levels in preeclamptic patients—a case control study. Int J Pharm Sci Rev Res. 2014;26:149–51.
23. Levine RJ, Hauth JC, Curet LB, Sibai BM, Catalano PM, Morris CD, et al. Trial of calcium to prevent preeclampsia. N Engl J Med. 1997;337:69–76.
24. Golmohammad S, Amirabi A, Yazdian M, Pashapour N. Evaluation of serum calcium, magnesium, copper, and zinc levels in women with preeclampsia. Iran J Med Sci. 2008;33:231–4.
25. Ehret GB, Caulfield MJ. Genes for blood pressure: an opportunity to understand hypertension. Eur Heart J. 2013;34:951–61.
26. Sethi S, Chaudhary A, Sonkhya P, Mital P, Arora A, Kasana VK, et al. A comparative study of serum calcium and magnesium levels in women with pre-eclampsia and normotensive women. Int J Reprod Contracept Obstet Gynecol. 2021;10:2420–6.
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