DENGUE VACCINES IN ENDEMIC SETTINGS: A LONG-AWAITED GAME CHANGER?
Keywords:
Dengue vaccine, Severe dengueAbstract
I read with great interest the article by Ramzan et al.¹ titled “Dengue Epidemics: Knowledge Perhaps is the Only Key to Success.” While public awareness and vector control remain essential strategies, the recent advancements in dengue vaccine development may represent a long-awaited turning point in the fight against this global health threat, particularly in endemic settings.
References
1. Ramzan M, Ansar A, Nadeem S. Dengue epidemics: knowledge perhaps is the only key to success. J Ayub Med Coll Abbottabad 2015;27(2):402–6.
2. Chang CY, Rajappan M, Zaid M, Ong ELC. Dengue fever complicated by hemophagocytic lymphohistiocytosis: Report of 2 cases and bone marrow findings. Clin Case Rep 2020;8(12):3427–3431.
3. Mashudi DN, Ahmad N, Mohd Said S. Level of dengue preventive practices and associated factors in a Malaysian residential area during the COVID-19 pandemic: A cross-sectional study. PLoS One 2022;17(4):e0267899.
4. World Health Organization. Dengue and severe dengue [Internet]. Geneva: WHO; 2023 [cited 2025 Aug]. Available from: https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue
5. Chem YK, Yenamandra SP, Chong CK, Mudin RN, Wan MK, Tajudin N, et al. Molecular epidemiology of dengue in Malaysia: 2015–2021. Front Genet 2024;15:1368843.
6. Bäck AT, Lundkvist A. Dengue viruses – an overview. Infect Ecol Epidemiol 2013;3:19839.
7. Malavige GN, Ogg GS. Pathogenesis of vascular leak in dengue virus infection. Immunology 2017;151(3):261–69.
8. Tejo AM, Hamasaki DT, Menezes LM, Ho YL. Severe dengue in the intensive care unit. J Intensive Med 2023;4(1):16–33.
9. Sangkaew S, Ming D, Boonyasiri A, Honeyford K, Kalayanarooj S, Yacoub S, et al. Risk predictors of progression to severe disease during the febrile phase of dengue: A systematic review and meta-analysis. Lancet Infect Dis 2021;21(7):1014–26.
10. Kok SY, Abraham RE, Jauhar Ali SN, Tuang WX, Ong ELC. A retrospective study of clinical biomarkers of severe dengue in a tertiary hospital in Johor Bahru, Malaysia. Trop Med Infect Dis 2025;10(2):30.
11. Thomas SJ. Is new dengue vaccine efficacy data a relief or cause for concern? NPJ Vaccines 2023;8(1):55.
12. Wilder-Smith A, Hombach J, Ferguson N, Selgelid M, O’Brien K, Vannice K, et al. Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine. Lancet Infect Dis 2019;19(1):e31–e38.
13. Tricou V, Yu D, Reynales H, Biswal S, Saez-Llorens X, Sirivichayakul C, et al. Long-term efficacy and safety of a tetravalent dengue vaccine (TAK-003): 4.5-year results from a phase 3, randomised, double-blind, placebo-controlled trial. Lancet Glob Health 2024;12(2):e257–70.
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