ASSOCIATION BETWEEN ALCOHOL USE DISORDER AND ISCHEMIC COLITIS: A CASE-CONTROL STUDY IN PAKISTANI PATIENTS

Authors

  • Tajali Noor Mohi Ud Din Islamic Medical College Mirpur AJK
  • Abrar Hussain Azad Mohi-ud-Din Islamic Medical College-Pakistan
  • Emaan Amjad Mohi Ud Din Islamic Medical College Mirpur AJK
  • Mahnoor Basharat Mohi Ud Din Islamic Medical College Mirpur AJK
  • Marwa Bibi Mohi Ud Din Islamic Medical College Mirpur AJK
  • Maimoona Samad Mohi Ud Din Islamic Medical College Mirpur AJK
  • Shaaray Abrar Umar CDA Hospital Islamabad-Pakistan
  • Pashma Wazir General Hospital Barakahu Islamabad-Pakistan

DOI:

https://doi.org/10.55519/JAMC-S4-14759

Keywords:

Ischemic colitis, alcohol use disorder, case-control study, smoking, Pakistan

Abstract

Background: Ischemic colitis (IC) represents a gastrointestinal condition which develops when reduced blood flow affects the colon leading to colon tissue inflammation and damage. Research shows alcohol use disorder as a possible risk factor for vascular diseases though its influence on the development of ischemic colitis remains unknown. Researchers aim to investigate how alcohol use disorder relates to ischemic colitis among Pakistani individuals. Methods: A case-control hospital-based study was conducted in different hospital settings in Pakistan. The research involved hundred participants diagnosed with IC as well as hundred participants who had similar demographics but lacked ischemic colitis. A standardized set of questionnaires gathered information about demographic characteristics in combination with comorbidities, smoking behavior, alcohol use patterns and diet. The evaluation of AUD used the Alcohol Use Disorders Identification Test (AUDIT). Logistic regression analysis with smoking, body mass index (BMI), diabetes and hypertension as control variables evaluated the associated between IC and AUD. Results: The prevalence of AUD was 20% in IC case subjects yet 14% in comparison participants though this difference proved statistically insignificant with a p value of 0.12. The analysis revealed that AUD alone showed no correlation with IC since the adjusted odds ratio equaled 1.3 with 95% confidence interval from 0.7 to 2.2 and a p value of 0.24. The analysis revealed smoking as a significant risk element for the development of IC (aOR = 1.9, 95% CI: 1.1–3.1, p=0.02). BMI and diabetes with hypertension displayed no meaningful relationships with ischemic colitis. Conclusion: AUD proved not to act as an independent factor for IC when confounders were accounted for throughout the analysis. The study revealed smoking behavior as the primary cause that leads to IC. More extensive prospective research is required to investigate how smoking and alcohol usage jointly create risks for developing IC.

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Published

2024-12-16

How to Cite

1.
Noor T, Azad AH, Amjad E, Basharat M, Bibi M, Samad M, et al. ASSOCIATION BETWEEN ALCOHOL USE DISORDER AND ISCHEMIC COLITIS: A CASE-CONTROL STUDY IN PAKISTANI PATIENTS. J Ayub Med Coll Abbottabad [Internet]. 2024 Dec. 16 [cited 2025 Aug. 17];36(4 (Suppl 1). Available from: https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/14759

Issue

Vol. 36 No. 4 (Suppl 1) (2024): JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD

Section

ORIGINAL ARTICLE

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Copyright (c) 2024 Tajali Noor, Abrar Hussain Azad, Emaan Amjad, Mahnoor Basharat, Marwa Bibi, Maimoona Samad, Shaaray Abrar Umar, Pashma Wazir

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