GESTATIONAL TROPHOBLASTIC DISEASE
Abstract
Background: Molar pregnancy represents a significant burden of disease on the spectrum ofGestational Trophoblastic Disease (GTD). The incidence appears to be quite high in South Asia. The
objective of this study was to determine the frequency of GTD, and clinical presentation, management
and outcome of patients with molar pregnancy. Methods: This retrospective, descriptive study was
conducted at Nuclear Institute of Medicine and Radiotherapy (NIMRA), Jamshoro from 1st Jan to 31st
Dec 2009. All patients diagnosed and registered as GTD were included in the study. The clinical
records of all molar patients were reviewed regarding presentation, treatment, and follow-up. Results:
There were a total of 167 patients presenting with different female genital tract neoplasia at NIMRA
during the study period, including 39 (29.35%) cases of GTD. Hydatidiform mole was seen in 33
(84.61%) patients. Complete mole in 31 (79.48%), partial mole in 2 (5.12%) patients, invasive mole in
1 (2.56%) patient, and choriocarcinoma in 5 (12.82%) patients. The mean age of the patients was
27±9.8 years. The highest incidence was found in nulliparous and para 1. Thirty-two patients had
suction evacuation and 1 patient underwent hysterectomy. Patients received chemotherapy, 17
(54.54%) patients followed protocol for 3-6 months. Conclusion: Frequency of molar pregnancy was
high, more common in low-parous, poor socioeconomic class women, and usually presented late.
Keywords: Gestational trophoblastic disease, Hydatidiform mole, management, outcome, women
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