FEASIBILITY AND SAFETY OF TRANSABDOMINAL CHORIONIC VILLUS SAMPLING
Abstract
Background: Chorionic Villus Sampling (CVS) is the technique of choice for prenatal diagnosis prior to12 weeks gestation. The objective of this study was to determine the feasibility, and pattern of
complications following first trimester Trans-abdominal Chorionic Villus Sampling (TA-CVS).
Methods: This was a descriptive study conducted in the Obstetrics and Gynaecology Department
Military Hospital (MH) Rawalpindi from Jan 2007 to July 2008. Couples at risk of giving birth to a child
with genetic disorder were identified and counselled. Trans-abdominal Chorionic Villus Sampling was
done using double needle technique under ultrasound guidance. Immediate and late complications were
followed up. Data was analysed using SPPS-10. Results: On 200 cases chorionic villus sampling was
done as an outdoor procedure. Most common indication was thalassaemia trait 75 (37.5%). Most
procedures were done between 12-13 weeks. All placental positions including 104 (52%) posterior and
71 (35.5%) anterior were approachable. Most aspirations were easy, however, in 30 (15%) the aspiration
was difficult. Overall success rate was 100%. In 158 (79%) of the cases sample yield was good. One
(0.5%) patient had vaginal bleeding and three (1.5%) had placental haematoma formation. Most patients
(84%) experienced mild pain during the procedure. The procedure related miscarriage occurred in 2
(1%) patients while another patient developed this complication after 6 weeks. Conclusion: First
trimester TA-CVS is an accurate and safe invasive prenatal diagnostic procedure. Placentas in almost
any position can be approached without any significant risk to mother and the foetus.
Keywords Prenatal diagnosis, thalassaemia, chorionic sampling
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