GENOTYPE VARIATION OF HEPATITIS C VIRUS IN DISTRICT BUNER SWAT
Abstract
Objective: To determine the frequency of various genotypes of Hepatitis C virus in District Buner,Swat. Methods: This Descriptive case series study was conducted at District Headquarter Hospital
Daggar, and Bilal Medical Trust, Pir Baba, Swat, Pakistan from January 2007 to June 2008. A
total of 400 patients, 154 Male and 246 Female aged 16-65 years (Mean age 31±13 years) without
clinical and ultrasonographic evidence of cirrhosis, and with positive Hepatitis C Virus (HCV)
antibodies by ELIZA, and HCV RNA detected by PCR were included. Hepatitis C virus
genotypes were checked in serum by real time PCR (RT-PCR). Results: Genotype 3 was the most
common type accounting for 61.5% of the study population. Amongst the subtypes, 182 (45.5%)
had genotype 3a and 64 (16%) had genotype 3b. Thirty-five (8.7%) patients had genotype 1a, 12
(3%) had genotype 1b. Twenty-six (6.5%) patients had genotype 2a. Four (1%) patients had
genotype 2b. Three (0.75%) patients had genotype 4a, and 1 (0.25%) had genotype 6a. Sixty-four
(16%) patients had mixed infections. Forty (10%) patients had genotype 3a and 3b, 12 (3%)
patients had genotype 1a, 1b, and 9 (2.25%) patients had genotype 2a and 1c, 2 (0.5%) had
genotype1a, 3a and 1 patient (0.25%) had genotype1a, 3b. Nine (2.25%) patients had untypable
genotype. Conclusion: Genotype 3 with its subtypes 3a and 3b is the commonest Hepatitis C virus
present in District Buner, Swat. The others in order of decreasing frequency are genotype 1a, 2a
and mixed types.
Keywords: Hepatitis C virus, HCV, Genotypes, District Buner
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