ROLE OF TUMOUR NECROSIS FACTOR IN PATHOGENESIS OF RADICULAR CYST

Authors

  • Waqar -ur-Rehman Qureshi
  • Muhammad Idris
  • Shahbaz Ali Khan

Abstract

Background: The radicular cyst is very common odontogenic cyst of the jaws, which is usually
associated with a tooth with necrotic pulp. The cyst formation requires proliferation of the epithelial rest
cells of Malassez present in the periodontal ligament. . Proliferation of epithelial rest cells of Malassez
is an essential event in the Pathogenesis of radicular cyst. The wall of the cyst contains epithelial cells,
macrophages, fibroblasts and other cells. TNF is one of inflammatory mediators, which is produced by
macrophages and monocytes. This study was carried out to investigate the role of tumour necrosis
factor in the pathogenesis of radicular cyst, which is by far the commonest cystic lesion of the jaws.
Methods: Explants from 20 radicular cysts were cultured in vitro to grow the epithelial cells.
However, the cultures were rapidly contaminated with fibroblasts and it was impossible to grow the
epithelial cells separately. Therefore, the proliferative effect of Tumour Necrosis Factor (TNF) was
studied on mammalian epithelial cells. Results: TNF at low concentration had a proliferative effect on
the epithelial cells, which may play some role in pathogenesis of radicular cyst. Conclusion: TNF
stimulated the epithelial cell proliferation in low concentration and inhibit the proliferation in higher
concentrations. These two effects may have some implications in the pathogenesis of radicular cyst.
Keywords: Tumour necrosis factor, epithelial rest cells of Malassez, macrophages and radicular cyst

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Published

2011-06-01

How to Cite

Qureshi, W. .- ur-R., Idris, M., & Khan, S. A. (2011). ROLE OF TUMOUR NECROSIS FACTOR IN PATHOGENESIS OF RADICULAR CYST. Journal of Ayub Medical College Abbottabad, 23(2), 87–89. Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/2540

Issue

Vol. 23 No. 2 (2011): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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