FREQUENCIES OF CONGENITAL ANOMALIES AMONG NEWBORNS ADMITTED IN NURSERY OF AYUB TEACHING HOSPITAL ABBOTTABAD, PAKISTAN
Abstract
Background: Congenital anomalies play a significant role in perinatal and neonatal morbidity andmortality. The frequency of these congenital anomalies varies in different populations. Objective
of this study was to find out the frequencies of congenital anomalies admitted in nursery of Ayub
Teaching Hospital, Abbottabad. Methods: In this descriptive, cross-sectional study all patients
admitted in NICU from October 2009 to January 2010 were included. The patients were examined
for major and minor congenital anomalies. The observations were recorded in tabulated form.
Results: A total of 2,360 patients were admitted in NICU during the study period. One hundred
patients were noted to have congenital anomalies. The most frequent anomalies involved the
central nervous system (31%). Meningomyelocele was the commonest defect (71%, 22 out of 31
cases of CNS defects), among these males were more (77%, 17 out of 22 of meningomyelocele
cases) than females (14 out of 31). These were followed by patients born with congenital heart
defects (16%). Patients with urogenital anomalies (6%) were all male except for one who had
ambiguous genitalia. Conclusions: Cases of meningomyelocele were the commonest presenting
congenital anomaly. More stress should be laid on the role of peri-conceptional vitamin
supplementation like folic acid for the primary prevention of congenital defects.
Keywords: congenital anomaly, birth defect, encephalocele, anencephaly, Down's syndrome, trisomy
References
Rosano A, Botto LD, Botting B, Mastroiacovo P. Infant mortality
and congenital anomalies from 1950 to 1994: an international
perspective. J Epidemiol Community Health 2000;54:660-6.
Agha MM, William JI, Marrett L, To Tl Dodds L. Detrimants of
survival in children with severe congenital anomalies: A long
term population based cohort study. Birth Defects Res A Clin
Mol Teratol 2006;76:46-54.
Harris JA, James L. State-by-state cost of birth defects-1992.
Tetrology 1997;56:11-6.
Abdi-Rad I, Khoshkalam M, Farrokh-Islamlou HR. The
Prevelance at Birth of OvertCongenital Anomalies in Urmia
Northwestern Iran. Arch Iran Med 2008;11(2):148-51.
Narchi H, Naji KIulayat N. Congenital malformation .Are they
more prevalent in cousin marriages. Ann Saudi Med
;17(2):254-6.
Wynshaw-Boris A, Biesecker LG. Dysmorphology. In:
Kliegman RM, Behrman RE. Editors. Nelson text book of
Pediatrics.18th Edition Philadelphia: Saunders; 2007;786-7.
Imaizumi Y, Yamamura H, Nishikawa M, Matsuoka M,
Moriyama I. The prevalence at birth of congenital malformations
at a maternity hospital in Osaka City, 1948-1990. Jinrui
Idengaku Zasshi 1991;36:275-87.
Chen CJ, Wang CJ, Yu MW, Lee TK. Perinatal mortality and
prevalence of major congenital malformations of twins in Taipei
City. Acta Genet Med Gemellol (Roma) 1992;41:197-203.
Evaluation of infant with single or multiple congenital
Anomalies. Guide lines American College of Medical genetics.
Available at: http://www.health.ny.gov/nysdoh/dpprd/exec.htm
Asindi AA, Al Hifzi I, Bassuni WA. Major congenital
malformations among Saudi infants admitted to Asir Central
Hospital.Annals of Saudi Medicine 1997;17:250-3.
Lee K, Khoshnood B, Chen L, Wall S, Cromie W, Mittendorf R.
Infant Mortality from Congenital Malformations in the United
States, 1990-97, Obstet Gynaecol 2000;98:620-7.
Mosayebi Z, Movahedian AH, Pattern of congenital
malformations in cosanguineous versus non consanguineous
marriages in Kashan, Islamic republic of Iran. Health J
;13:868-75.
Abdulrazzaq YM, Bener A, Al-Gazali LI, Al-Khayat AI,
Micallef R, Gaber T. A study of possible deleterious effects of
consanguinity. Clinical Genetics 1997;51:167-73.
Muga RO, Mumah SCJ, Juma PA. Congenital malformations
among newborns in Kenya, Afr J food Agri Nutr Dev
;l9:819-29.
Downloads
Published
How to Cite
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
