PERCENTAGE OF CD4+ AND CD8+ T-LYMPHOCYTES IN BLOOD OF TUBERCULOSIS PATIENTS

Authors

  • Nadeem Afzal
  • Khursheed Javed
  • Saleem -uz- Zaman
  • Asim Mumtaz
  • Shahid Hussain
  • Romeeza Tahir
  • Ikram Ullah
  • Muhammad Akram

Abstract

Background: Tuberculosis is a fatal infectious disease, mainly caused by Mycobacterium
tuberculosis. Spread of TB is controlled by cell-mediated immunity. Purpose of this study was to
determine CD4+ and CD8+ T cell percentages in TB patients. Methods: 77 subjects consisted of
39 patients of active tuberculosis and 37 normal healthy individuals were recruited for the study.
Among patients, 27 were at different stages of anti-tuberculous therapy while rests of the patients
were not taking treatment. Sixteen patients were sputum positive for AFB while other patients
were sputum negative for AFB. T cells percentages were determined by flow cytometer. Results:
In TB patients CD4+ and CD8+ T cells percentages were 34.4±9.8 and 32.0±9.8 while in controls
these were 37.1±6.9 and 30.2±7.2 respectively but the difference was statistically insignificant.
CD4+ T cell percentage in newly diagnosed TB patients was 28.8±8.7 while it was 37.9±8.9 in TB
patients who were on therapy and difference was statistically significant whereas difference in
CD8+ T-cell percentages was statistically insignificant. A negative correlation between CD8+ Tcells percentage and the duration of ATT was found. Conclusion: CD4+ and CD8+ T-cells
percentages may help to find out the immune status of TB patients before and after the completion
of ATT.
Keywords: TB, CD4+, CD8+, ATT, AFB

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Published

2010-12-01

How to Cite

Afzal, N., Javed, K., Zaman, S. .- uz-., Mumtaz, A., Hussain, S., Tahir, R., … Akram, M. (2010). PERCENTAGE OF CD4+ AND CD8+ T-LYMPHOCYTES IN BLOOD OF TUBERCULOSIS PATIENTS. Journal of Ayub Medical College Abbottabad, 22(4), 182–186. Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/2745

Issue

Vol. 22 No. 4 (2010): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

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ORIGINAL ARTICLE

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