LINDANE TOXICITY IN A 7 YEAR OLD BOY

Authors

  • Yousaf Daud
  • Daud -ur- Rehman
  • Umer Farooq

Abstract

Lindane (gamma-benzene hexachloride) is widely used as a scabicide by general practitioners and
dermatologists in Pakistan. We present a case of a 7 year old boy who had suffered from scabies 1
week ago, for which he was prescribed lindane along with other medications by a general practitioner.
After 3 application of lindane the child began to experience Grand mal seizures, ataxia, weakness,
incoordination and severe burning paresthesias. Lindane is known to cause neurotoxicity and for this it
has been recommended as a 2nd line treatment for scabies by FDA.
Keywords: lindane, scabicide, topical application, toxicity, adverse effects, neurotoxic, children

References

Center for Drug Evaluation and Research. US Food and Drug

Administration; 2003. [updated 2003 Mar 28; cited 2008 Nov 1].

FDA public health advisory: safety of topical lindane products

for the treatment of scabies and lice [Internet] Available from:

http://www.fda.gov/cder/drug/infopage/lindane/lindanePHA.htm.

McCarthy JS, Kemp DJ, Walton SF. Scabies, more than just an

irritation. Postgrad Med J 2004;80:382-7.

Thomas DR, McCarroll L, Roberts R, P Karunaratne, C Roberts,

D Casey, et al. Surveillence of insecticide resistance in headlice

using biochemical and molecular methods. Arch Dis Child

;91:777-8.

Persistent organic pollutant review committee. Draft risk

management evaluation for Lindane. [Internet] Available from:

http://www.pops.int/documents/meetings/poprc/drprofile/drme/D

raftRME_Lindane.pdf

Agency for toxic substances and disease registry, US department

of health and human services; Toxicological profile for alpha,

beta, gamma and delta hexachlorocyclohexane. August 2005.

Available at: http://www.atsdr.cdc.gov/toxprofiles/tp43.pdf

Telch J, Jarvis D. Acute intoxication with Lindane. Can Med

Assoc J 1982.126:662-3.

Mala Bhalla MD, Gurvinder P Thami MD. Reversible

neurotoxicity after an overdose of topical lindane in an infant.

Pediatr Dermatol 2004;21:597-9.

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Published

2010-12-01

How to Cite

Daud, Y., Rehman, D. .- ur-., & Farooq, U. (2010). LINDANE TOXICITY IN A 7 YEAR OLD BOY. Journal of Ayub Medical College Abbottabad, 22(4), 223. Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/2756