MINIMAL CHANGE DISEASE, THE LEADING CAUSE OF GLOMERULOPATHIES IN PAEDIATRIC POPULATION AT PESHAWAR

Authors

  • Ahmad Zeb Khan
  • Aziz Ahmad

Abstract

Background: Glomerulonephritis (GN) is a relatively rare disease with numerous subtypes. Most
regional nephrology centres see only a limitednumber of patients with each type of GN every year. The
objective of this study was to find out the pattern of glomerulopathies in paediatric population,
undergoing renal biopsy in Peshawar. Methods: This was a prospective study carried out at the
Department of Nephrology, Khyber Teaching Hospital, Peshawar from May 2002 to May 2004.
Ultrasound guided percutanous renal biopsies were carried out in patients with the findings of: 1)
Nephrotic range proteinuria in children, 2) Non-nephrotic range proteinuria with evidence of
hypertension/haematuria/deranged renal function or active sediments on urine microscopy, 3) Steroid
resistant nephrotic syndrome in children, and 4) Children with nephrotic syndrome who were not
tolerant of steroid therapy or were considered for immunosuppressive drugs. Results: A total of 155
renal biopsies were taken. Out of these 90 were male patients and 65 were female. The most common
histopathological lesion among children population was Minimal Change Disease (42.66%) followed
by Focal Segmental Glomerulosclerosis (25.33%) and Membranous Glomerulonephritis (16.0%).
Nephrotic range proteinuria was most prevalent in Minimal Change Disease and Membranous
Glomerulonephritis followed by Focal Segmental Glomerulosclerosis. Non-nephrotic range proteinuria
was mostly seen in patients with Membranoprolifirative Glomerulonephritis. Conclusion: In paediatric
population, Minimal Change Disease is the most commonly encountered glomerulopathy, followed by
Focal Segmental Glomerulosclerosis and Membranous Glomerulonephritis.
Keywords: Nephrotic Syndrome, Renal biopsy, Proteinuria, Glomerulopathy

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Published

2010-06-01

How to Cite

Khan, A. Z., & Ahmad, A. (2010). MINIMAL CHANGE DISEASE, THE LEADING CAUSE OF GLOMERULOPATHIES IN PAEDIATRIC POPULATION AT PESHAWAR. Journal of Ayub Medical College Abbottabad, 22(2), 26–28. Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/2936

Issue

Vol. 22 No. 2 (2010): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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