ROLE OF INTERLEUKIN-1 IN PATHOGENESIS OF RADICULAR CYST

Authors

  • Waqar ur Rehman Qureshi
  • Muhammad Asif
  • Iftikhar Hossein Qari
  • Javed Akhtar Qazi

Abstract

Background: Interleukin-1 (IL-1) is one of the cytokines produced by macrophages, monocytes and
dentritc cells. Macrophages are present in apical granuloma and the wall of the radicular cyst. This
cytokine causes the cyst expansion and is involved in proliferation of fibroblasts in the cyst wall and
stimulate the fibroblasts to produce more prostaglandin. Radicular cyst is the most common cyst of the
jaws which is usually associated with necrotic pulp of the tooth. The cyst formation requires
proliferation of the epithelial rest cells of Malassez present in the periodontal ligament. Proliferation of
epithelial rest cells of Malassez is an essential event in the Pathogenesis of radicular cyst. Objective of
the study was to investigate the effect of IL-1 on epithelial cell proliferation which is an important
factor in the pathogenesis of radicular cyst. Methods: The cyst walls of 20 radicular cysts were
removed and were cultured in vitro to grow the epithelial cells. The culture were rapidly contaminated
and dominated by growth of fibroblasts. Therefore another cell line was used for the experiments.
Results: The result showed that proliferation was stimulated with increased in a biphasic manner with
maximum stimulation at 1.25 ηg/ml, beyond this concentration proliferation was decreased.
Conclusion: IL-1 had a proliferative effect on epithelial cells at low concentrations which may be
playing a role in evoking an inflammatory reaction and stimulating the epithelial cell rests of Malassez
to proliferate to form radicular cyst.
Keywords: Interleukin-1, radicular cyst, epithelial cell rests of Malassez, Epithelial cell proliferation

References

Malik NA. The cysts of the jaws and facial soft tissues In Text

book of oral & maxillofacial Surgery. 2nd Ed. New Dehli Jaypee

Brothers. Medical Publishers (P) Ltd. 2008. p.448-9.

Seward GR, Harris M, McGown DA. Killey's and Kay's outlines

of Oral Surgery. Part I 2nd Ed. Wright Bristol 1987;65-6.

Tencate A R. The epithelial cell rests of Malassez and genesis of

the dental cysts. Oral Surg 1972;34:956-64.

Muglali M, Komerik N, Bulut E, Yrim GF, Celeb N, Sumer M.

Cytokines and chemokine level in Radicular residual cyst fluid J

Oral Pathol Med 2008;37(3):185-9.

Colic S, Jurisic M, Jurisic V. Pathogophysiological mechanism

of the developing maxillofacial radicular cyst. Acta Chirugoi

Iugoslavica 2008;55(1):87-92.

Meghji S, Harvey W, Harris M. Interleukin-I like activity in

cystic lesions of the jaws. Br J Oral Maxillofac Surg 1989;27:1-

Hume WJ, Moore JK, Main DMG. Differences in vitro growth

of epithelium form inflammatory and developmental odontogenic

cysts. Br J Oral Maxillofac Surg 1990;28:85-8.

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Published

2010-06-01

How to Cite

Qureshi, W. ur R., Asif, M., Qari, I. H., & Qazi, J. A. (2010). ROLE OF INTERLEUKIN-1 IN PATHOGENESIS OF RADICULAR CYST. Journal of Ayub Medical College Abbottabad, 22(2), 86–87. Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/2952

Issue

Vol. 22 No. 2 (2010): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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