CALCIUM STATUS IN PREMENOPAUSAL AND POSTMENOPAUSAL WOMEN
Abstract
Background: In postmenopausal women, the two major causes of bone loss are oestrogendeficiency after menopause and age related processes. Bone turnover increases to high levels and
oestrogen deficiency may induce calcium loss by indirect effects on extra skeletal calcium
homeostasis. Objective of this study was to evaluate calcium status in pre-menopausal and
postmenopausal women. Methods: This cross sectional study was carried out in 34
premenopausal women and 33 postmenopausal women, in Department of Physiology, Services
Institute of Medical Sciences, Lahore. Height and weight of each woman were taken to find out
the body mass index (BMI). Serum calcium, parathyroid hormone and calcitonin levels of each
subject were determined. Results: Premenopausal women were obese (BMI>30 Kg/m2) while
postmenopausal women were overweight (BMI>25 Kg/m2). Serum calcium levels were
significantly lower in postmenopausal women than in pre-menopausal women, while serum
parathyroid hormone levels were significantly higher in postmenopausal woman. Serum calcitonin
level was not significantly different in the two groups. Conclusion: Postmenopausal women are
calcium deficient and have increased bone turnover as indicated by increased serum parathyroid
hormone levels.
Keywords: Premenopausal, postmenopausal, calcium, parathyroid hormone, calcitonin.
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