A RETROSPECTIVE STUDY OF OVARIAN TUMOURS AND TUMOUR-LIKE LESIONS
Abstract
Background: Ovaries are common site of non-neoplastic and neoplastic lesions. They can presentfrom the neonatal period to post menopause. Most are functional in nature and resolve with minimal
treatment. Objective of the study was to determine the nature of various ovarian lesions and to ascertain
the frequency and distribution of the various non-neoplastic and neoplastic lesions. Methods: The
study was a retrospective review of all cases of ovarian cancer, benign ovarian neoplasm and functional
ovarian cysts received during Jan-Dec 2008 at Chughtai's Lahore Laboratory. The clinical data of the
patients was obtained from their respective files. Results: A total of 498 different non-neoplastic and
neoplastic lesions were seen during one calendar year 2008. Non-neoplastic cysts were more common
(343, 68.87%) than neoplastic tumours (155, 31.12%). The commonest non-neoplastic cyst was luteal
cyst followed by follicular cyst. Among the neoplastic tumours 78.70% were benign and 21.29% were
malignant. Benign serous cysts were the commonest benign tumour followed by mature cystic teratoma
and mucinous cyst. Serous cystadenocarcinoma was the commonest malignant tumour followed closely
by endometrioid carcinoma and granulosa cell tumour. Krukenberg tumour, tumour metastatic to
ovaries and non-Hodgkins lymphoma was also diagnosed during this period. Malignant germ cell
tumours were seen in much younger age group followed by sex cord stromal tumours. Epithelial
tumours were seen in much older age group. Conclusion: The morphologic diversity of ovarian masses
poses many challenges. A specific diagnosis can usually be made by evaluating routinely stained slides
but sometimes immunohistochemistry is required in difficult cases. Gross features also provide useful
diagnostic clues.
Keywords: Ovarian functional cysts, ovary, ovarian neoplasm
References
Grimes DA, Jones LB, Lopez LM, Schulz KF. Oral
contraceptives for functional ovarian cysts. Cochrane
Database Syst Rev 2006;4:CD006134.
Holt VL, Cushing-Haugen KL, Daling JR. Risk of
Functional Ovarian Cyst: Effects of Smoking and Marijuana
Use according to Body Mass Index. Am J Epidemiol
;161:520-5.
Clement PB. Selected miscellaneous ovarian lesions: small
cell carcinomas, mesothelial lesions, mesenchymal and
J Ayub Med Coll Abbottabad 2010;22(1)
http://www.ayubmed.edu.pk/JAMC/PAST/22-1/Samina.pdf
mixed neoplasms, and non-neoplastic lesions. Modern Pathol
;18:113-29.
Shah S, Hishikar VA. Incidence and Management of Ovarian
Tumors. Bombay Hospital J 2008;50(1):30-3.
Stewart SL, Querec TD, Ochman AR, Gruver BN, Bao R,
Babb JS, et al. Characterization of a Carcinogenesis Rat
Model of Ovarian Preneoplasia and Neoplasia. Cancer Res
;64:8177-83
Auersperg N, Wong AST, Choi KC, Kang SK, Leung PCK.
Ovarian Surface Epithelium: Biology, Endocrinology, and
Pathology. Endocr Rev 2001;22(2):255-88.
Jung SE, Lee JM, Rha SE, Byun JY, Jung JI, Hahn ST. CT
and MR Imaging of Ovarian Tumors with Emphasis on
Differential Diagnosis. Radiographics 2002;22:1305-25.
Ness RB, Grisso JA, Cottreau C, Klapper J, Vergona R,
Wheeler JE, et al. Factors Related to Inflammation of the
Ovarian Epithelium and Risk of Ovarian Cancer.
Epidemiology 2000;11(2):111-7
Zhang J, Ugnat AM, Clarke K, Mao Y. Ovarian cancer
histology-specific incidence trends in Canada 1969-1993:
age-period-cohort analyses. British Journal of Cancer
;81(1):152-8.
Herbst AL. The Epidemiology of Ovarian Carcinoma and the
Current Status of Tumor Markers to Detect Disease. Am J
Obstet Gynecol 1994;170:1099-107.
Mesogitis S, Daskalakis G, Pilalis A, Papantoniou N,
Thomakos N, Dessipris N, et al. Management of Ovarian
Cysts with Aspiration and Methotrexate Injection. Radiology
;235:668-73.
De Kroon CD, Van der Sandt HAGM, Van Houwelingen JC,
Jansen FW. Sonographic assessment of non-malignant
ovarian cysts: does sonohistology exist? Hum Reprod
;19(9):2138-43.
Gupta N, Bisht D, Agarwal AK, Sharma VK. Retrospective
and prospective study of ovarian tumors and tumor like
lesions. Indian J Pathol Microbiol 2007;50:525-7.
Wasim T, Majrroh A, Siddiq S. Comparison of clinical
presentation of Benign and Malignant Ovarian Tumors. J Pak
Med Assoc 2009;59(1):18-21.
Choi HJ, Kim SH, Kim HC, Park CM, Lee HJ, Moon MH, et
al. Ruptured Corpus Luteal Cyst: CT Findings. Korean J
Radiol 2003;4:42-5.
Averette HE, Donato DM. Ovarian carcinoma, advances in
diagnosis, staging and treatment. Cancer 1990;65:703-8.
Memon MH, Memon I, Memon RA. The changing pattern of
malignant diseases in Sindh province. Pak J Pathol
;3:17-20.
Ong HC, Chan WF. Mucinous cystadenoma, serous cyst
adenoma and benign cystic teratoma of ovaryclinicopathologic differences observed in Malaysian hospital.
Cancer 1978;41:1538-42.
Jeong YY, Outwater EK, Kang HK. Imaging evaluation of
ovarian masses. Radiographics 2000; 20:1445-70.
Kawamoto S, Urban BA, Fishman EK. CT of epithelial
ovarian tumors. Radiographics 1999;19:S85-S102.
Koonings PP, Campbell K, Mishell DR Jr, Grimes DA.
Relative frequency of primary ovarian neoplasms: a 10-year
review. Obstet Gynecol 1989;74:921-6.
Rafiq B, Kokab H, Rao SI. Ovarian tumors. Professional
Med J 2005;12(4):397-403.
Levi1 F, Vecchia CL, Randimbison L, Te VC. Borderline
ovarian tumors in Vaud. Switzerland: incidence, survival and
second neoplasms. Br J Cancer 1999;79(1):4-6.
Burkholz KJ, Wood BP, Zuppan C. Best Cases from the
AFIP: Borderline papillary serous tumor of the right ovary.
Radiographics 2005;25:1689-92.
Moon WJ, Koh BH, Kim SK, Kim YS, Rhim HC, Cho OK,
et al. Brenner tumor of the ovary: CT and MR findings. J
Comput Assist Tomogr 2000;24:72-6.
Outwater EK, Siegelman ES, Kim B, Chiowanich P,
Blasbalg R, Kilger A. Ovarian Brenner tumors: MR imaging
characteristics. Magn Reson Imaging 1998;16:1147-53.
Outwater EK, Siegelman ES, Hunt JL. Ovarian teratomas:
tumor types and imaging characteristics. Radiographics
;21:475-90.
Jung SE, Rha SE, Lee JM, Park SY, Oh SN, Cho KS, et al.
CT and MRI Findings of Sex Cord-Stromal Tumor of the
Ovary. AJR Am J Roentgenol 2005;185:207-15.
Baker PM, Oliva E. Immunohistochemistry as a Tool in the
Differential Diagnosis of Ovarian Tumors: An Update. Int J
Gynecol Pathol 2005;24(1):39-55.
McCluggage WG, Young RH. Immunohistochemistry as a
diagnostic aid in the evaluation of ovarian tumors. Semin
Diagn Pathol 2005;22(1):3-32.
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