OBESITY, HYPERLIPIDEMIA, AND HYPERURAECEMIA IN YOUNG AND OLD HYPERTENSIVE PATIENTS

Authors

  • Nazir Ahmed
  • Waqas Anwar
  • Huma Waqas

Abstract

Background: There is strong correlation among hypertension, obesity, hyperlipidemia and
hyperuricemia which are important risk factor for the cardiovascular disease. Objective of this study
was to assess and compare the prevalence of obesity, hyperlipidemia and hyperuricemia among
young and old hypertensive patients in the local setting. Methods: This cross-sectional study was
conducted at medical Out-patient Department at Shahina Jamil Teaching Hospital, Abbottabad, from
September 2007 to February 2008. Eighty-six patients seen in the medical outpatient department
were enrolled in the study. Patients with age 15 years or above and diagnosed as case of systemic
hypertension were included. Patients with endocrine disease, pregnancy, coarctation of aorta, and
renal disease leading to hypertension were excluded from the study. Results: Total eighty-six
patients with mean age of 53.7±12.9 years were included in the study. Patients were divided into
younger age group (age <46 years) and older age group (age ‰¥46 years). Mean Body Mass Index
(BMI) was 29.7±5.2 in the younger age group and 26.9±4.7 in the older age group, mean serum
cholesterol level was 192.2±14.2 mg/dL in younger age group and 190.9±18.3 mg/dL in the older
age group, mean serum triglyceride level was 170.5±13.7 mg/dL in younger age group and
166.6±21.4 mg/dL in the older age group and mean serum uric acid levels were 5.6±0.7 mg/dL in
younger age group and 5.7±1.2 mg/dL in the older age group. Overweight and obese patients were
70.9% with its higher prevalence in younger (86.2%) as compared to older patients (63.2%).
Hypercholesterolemia was found in 27.9% of the patients, with a frequency of 24.1% in younger
patients and 29.8% in the older patients. Hypertriglyceridemia was seen in 66.3% of the patients,
with a frequency of 69.0% in younger patients and 64.9% in the older patients. Hyperuricemia was
present in 37.2% of the hypertensive patients with a frequency of 34.5% in the younger patients and
38.6% in the older patients. Conclusion: Hypercholesterolemia, hypertriglyceridemia, and
hyperuricemia are not associated with the age of the hypertensive patients. Increased BMI is more
frequent in the young as compared to the old hypertensive patients.
Keywords: hypertension, obesity, hypercholesterolemia, hypertriglyceridemia, hyperuricemia

References

Jousilahti P, Tuomilehto J, Vartiainen E, Valle T, Nissinen A.

Body mass index, blood pressure, diabetes and risk of antihypertensive drug treatment: 12 years follow-up of middle-aged

people in eastern finland. J Hum Hypertens 1995;9:847-54.

Rana TF, Mahmood S, Ahmad M, Akhtar RM. Assessment of

Body Mass index (BMI) in medical students (a cross sectional

Survey) Ann King Edward Med Coll 2006;12:545-6.

Jones DW, Kim JS, Andrew ME, Kim SJ, Hong YP. Body mass

index and blood pressure in Korean men and women: the Korean

National Blood Pressure Survey. J Hypertens 1994;12:1433-7.

Doll S, Paccaud F, Bovet P, Burnier M, Wietlisbach V. Body

mass index, abdominal adiposity and blood pressure: consistency

of their association across developing and developed countries.

Int J Obes Relat Metab Disord 2002;26:48-57.

Dyer AR, Liu K, Walsh M, Kiefe C, Jacobs DR Jr, Bild DE.

Ten-year incidence of elevated blood pressure and its predictors:

the CARDIA Study Coronary Artery Risk Development in

(Young) Adults. J Hum Hypertens 1999;13:13-21.

Juhaeri Stevens J, Chambless LE, Tyroler HA, Rosamond W,

Nieto FJ, Schreiner P, et al. Associations between weight gain

and incident hypertension in a bi-ethnic cohort: the

Atherosclerosis Risk in Communities Study. Int J Obes Relat

Metab Disord 2002;26:58-64.

Miller ER, Erlinger TP, Young DR, Jehn M, Charleston J,

Rhodes D, et al. Results of the Diet, Exercise, and Weight Loss

Intervention Trial (DEW-IT). Hypertension 2002;40:612-8.

Masuo K, Mikami H, Ogihara T, Tuck ML. Weight gain-induced

blood pressure elevation. Hypertension 2000;35:1135-40.

Huang Z, Willett W, Manson J, Rosner B, Stampfer M, Speizer

F. Body weight, weight change, and risk for hypertension in

women. Ann Intern Med 1998;128:81-8.

Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz

WH. The disease burden associated with overweight and obesity.

JAMA 1999;282:1523-9.

J Ayub Med Coll Abbottabad 2009;21(4)

http://www.ayubmed.edu.pk/JAMC/PAST/21-4/Nazir.pdf

Zhang X, Sun Z, Zheng L, Li J, Liu S, and Xu C. Prevalence of

dyslipidemia and associated factors among the hypertensive rural

Chinese population. Arch Med Res 2007;8:432-9.

Zhang X, Patel A, Horibe H, Wu Z, Barzi F, Rodgers A, et al.

Cholesterol, coronary heart disease, and stroke in the Asia Pacific

region. Int J Epidemiol 2003;32:563-72.

Jafar TH, Chaturvedi N, Pappas G, Prevalence of overweight and

obesity and their association with hypertension and diabetes

mellitus in an Indo-Asian population. CMAJ 2006;175:1071-7.

National Heart, Lung and Blood Institute. Report of the expert

panel on detection evaluation and treatment of high blood

cholesterol adult. National cholesterol education programme.

Washington DC, US Department of Health and Human Services,

Executive summary of the Third Report of the National

Cholesterol Education Programme (NECP) Expert Panel on

Detection, Evaluation, and Treatment of High Blood Cholesterol

in Adult (Adult Treatment Panel III). JAMA. 2001;285:2486-97.

Ezeanyika LUS, Ugwu CE, Nwanguma BC, Onah LE, Ojobo C,

Abba V. Assessment of cardiovascular disease risk factors of an

urban Nigerian hypertensive population using a risk score

calculator. Pak J Med Sci 2008;24:390-94.

Burchfiel CM, Abbott RD, Sharp DS, Curb JD, Rodriguez BL,

Yano K. Distribution and correlates of lipids and lipoproteins in

elderly Japanese-American men. The Honolulu Heart Program.

Arterioscler Thromb Vasc Biol 1996;16:1356-64.

Baloch AA, Siddiqui S, Tariq H, Hamid SY, Shaikh Z

Hypertension and obesity. Med Channel 2008;14:22-4.

Brown CD, Higgins M, Donato K A, Rohde FC, Garrison R,

Obarzanek E. Body mass index and the prevalence of

hypertension and Dyslipidemia. ObesRes 2000;8:605-19.

Shaikh MA, Qazi RA. Hypercholesterolemia in hypertensive

patients. Ann Pak Inst Med Sci 2005;1:142-5.

Sattar RA, Ahmed S, Hussain S, Irtiaz Rizvi SM, Ara J.

Frequency of lipid abnormalities in essential hypertension. J Surg

Pak 2002;4:2-4.

Rehman A, Sattar A, Abaidullah S, Hassan M. Evaluation of

Cardiovascular Risk Factors in Patients with Essential

Hypertension. Ann King Edward Med Coll 1999;5:134-7.

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Published

2009-12-01

How to Cite

Ahmed, N., Anwar, W., & Waqas, H. (2009). OBESITY, HYPERLIPIDEMIA, AND HYPERURAECEMIA IN YOUNG AND OLD HYPERTENSIVE PATIENTS. Journal of Ayub Medical College Abbottabad, 21(4), 53–56. Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/3142