SERUM ADIPONECTIN LEVELS IN PATIENTS WITH CORONARY ARTERY DISEASE
Abstract
Background: Adiponectin is an adipocytokine secreted from white adipose tissue. Serum level ofadiponectin has been shown to be reduced in several disease states like obesity and diabetes.
Hypoadiponectinemia has also been included in the list of newer risk factors for Coronary Artery
Disease (CAD). Methods: In this analytical cross-sectional study serum adiponectin level was
measured by Enzyme Linked Immunosorbant Assay (ELISA) in 60 cases of coronary artery
disease (CAD) (both sexes, aged 40-60 yrs) and 60 healthy controls. Results: Low levels of
adiponectin were seen in CAD patients as well as controls. These levels were lower as compared
to western standards. Conclusion: Our study conforms to the previous observation of lower serum
adiponectin levels in South Asians compared to the western standards. Serum adiponectin level
should be considered in the laboratory work-up of CAD patients.
Keywords: Coronary Artery Disease (CAD), adiponectin, hypoadiponectinemia, adipocytokine,
Enzyme Linked Immunosorbant Assay (ELISA)
References
Scherrer PE, Williams S, Fogliano M, Baldini G, Lodish HF A
novel serum protein similar to c1q produced exclusively in
adipocytes. J Biol Chem 1995;270:26746-9.
Hu E, Liang P, Spiegelman. AdipoQ is a novel adipose-specific
gene dysregulated in obesity. J Biol Chem 1996;271:10697-703.
Maeda K, Okubo K, Schimomura L, Funahashi T, Matsuzawa Y,
Matsubara K. cDNA cloning and expression of a novel adipose
tissue collagen like factor , apM1 (adipose most abundant gene
transcript 1). Biochem Biophys Res Commun 1996;221:286-9.
Nakano Y, Tobe T, Choi-Mura NH, Mazda T, Tomita M.
Isolation and characterization of GBP28, a novel gelatin-
binding protein purified from human plasma. J Biochem
;120:803-12.
Gil-Campos M, Canete R, Gil A. Adiponectin, the missing link
in insulin resistance and obesity. Clin Nutr 2004;23:963-74.
Hopkins TA, Ouchi N, Shibata R, Walsh K. Adiponectin actions
in the cardiovascular system. Cardiovasc Res 2007;74:11-8.
Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and
disease. Diabetes Obes Metab 2007;9:282-9
Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, O
Yoshihisha, et al. Plasma concenteration of a novel adipose
specific protein, adiponectin, in type 2 diabetic patients.
Arteriscler Thromb Vasc Biol 2000;20:1595-9.
Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm
EB. Plasma adiponectin levels and risk of myocardial infarction
in men. JAMA 2004;291:1730-7.
Retnakaran R., Hanley A, Zinman B. Does hypoadiponectinemia
explain the increased risk of diabetes and cardiovascular disease
in South Asians? Diabetes Care 2006;29:1950-4.
Vishwanathan M, Deepa R, Deepa R, Vimaleswaran KS, Mohan
A, Velmurugan K et al. Association of low adiponectin levels
with the metabolic syndrome-the Chennai Urban Rural
Epidemiology Study (CURES-4). Metabolism 2004;54: 476-8.
Valsamakis G, Chetty R., McTernan PG, Al-Daghri NM,
Barnett AH, Kumar S. Fasting serum adiponectin concentration
is reduced in Indo-Asian subjects and is related to HDL
cholesterol. Diabetes Obes Metab 2003;5:131-5.
Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S,
Ouchi N, et al. Association of hypoadiponectinemia with
coronary artery disease in men. Arterioscler Thromb vasc Biol
;23:85-9.
J Ayub Med Coll Abbottabad 2009;21(4)
http://www.ayubmed.edu.pk/JAMC/PAST/21-4/Iram.pdf
Abate N, Chandali M, Snell PG and Grundy SM. Adipose tissue
metabolites and insulin resistance in non diabetic Asian Indian
men. J Clin Endocrinol Metab 2004;89:2750-5.
Mahmud A, Feely J. Adiponectin and arterial stiffness. Am J
Hypertens 2005;18:1543-8.
Matsubara M, Maruoka S, Katayose S. Decreased plasma
adiponectin concentrations in women with dyslipidemia. J Clin
Endocrinol Metab 2002;87:2764-9.
Kistorp C, Faber J, Galatius S, Gustafsson F, Frystyk J,
Flyvbjerg A, et al. Plasma adiponectin, body mass index, and
mortality in patients with chronic heart failure.
Circulation.2005;112:1756-62.
Kojima S, Funahashi T, Sakamoto T, Miyamoto S, Soejima H,
Hokamaki J, et al. The variation of plasma concenterations of a
novel, adipocyte derived protein, adiponectin, in patients with
acute myocardial infarction. Heart 2003; 89:667-8.
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