EFFECT OF RACE, GENDER AND AGE ON THYROID AND THYROID STIMULATING HORMONE LEVELS IN NORTH WEST FRONTIER PROVINCE, PAKISTAN
Abstract
Background: Thyroid is one of the ductless endocrine gland, which is located immediately belowthe larynx on either side of and anterior to the trachea. The principal hormones of thyroid gland
are thyroxine (T4) and triiodothyronine (T3). The current study was carried out to investigate the
impact of race, gender and area on the levels of Thyroxine (T4), Triiodothyronine (T3) and Thyroid
Stimulating Hormone (TSH) in normal healthy individuals. Methods: Serum levels of T4, T3 and
TSH in 498 normal healthy individuals belonging to different districts of North West Frontier
Province, Pakistan, were examined. Serum T4 and T3 were analysed by Radio Immuno Assay
(RIA) method whereas TSH was estimated by Immunoradiometric assay (IRMA) method.
Results: Levels of T4, T3 and TSH ranged from 53 to 167 ηmol/L, 0.6 to 3.1 ηmol/L and 0.3-4.8
µIU/L respectively. The levels of these hormones show significant change from the reference
values that are used in clinical laboratories as well as in Institute of Radiotherapy and Nuclear
Medicine (IRNUM), Peshawar, Pakistan. Conclusion: It is concluded that the age, gender, race
and area, all have an appreciable effect on the levels T4, T3 and TSH.
Keywords: Thyroxine, Triiodothyronine, Thyroid Stimulating Hormone, TSH, Thyroid Hormones
References
Ganong. FW. Review of Medical Physiology, California:
Appleton and Lange; 1995. p.314.
Guyton WC, Hall 1E. A Textbook of Medical Physiology.
Philadelphia: W B Saunders & Co; 1996. p. 945-55.
Edwards R. Immunoassay (An Introduction), London:
William Heinemann Medical Book; 1985. p. 84, 685.
Griffin, I E.; Objeda, S. R. The Textbook of Endocrine
Physiology. New York: Oxford University Press; 1988.
pp.222 & 232.
Andreali TE, Carpenter CC1, Bannet, 1C, Plum F. Cecil
Textbook of Medicine, 4th Edition. Philadelphia: W.B.
Saunder & Co; 1997. p. 952-3.
Murry RK, Gerner PK, Mays PA, Rodwell VW. Harper's
Textbook of Biochemistry, 25th Edition. Appleton & Lange:
Stanford, 2000; p. 8.
Thorell, IL; Larson, S.M. Radioimmunoassay and related
techniques (Methodology and Clinical Applications). Saint
Louis: The CV Mosby Company; 1978. p.12, 119.
Razzak, MA. Effect of Age and Sex on Thyroid Function
Tests. Establishment of norms for the Egyptian Population in
Developments in Radioimmunoassay and Related Procedures
International Atomic Energy Agency, 1992. p.353-8.
Dashe JS, Casey BM,Well CE, Mc Intrire DD, TSH in single
and twin pregnancy ; important if gestational age - specific
reference ranges. Obstet Gynecol 2005;106:753-7
Wilson ID, Foster DW. William's Textbook of
Endocrinology, 8th Edition. Philadelphia: WB. Saunders &
Co; 1992. p.358-80.
Hollander CS, Nihei N, Burday SZ, Mitsuma T, Shenkman
L, Blum M. Clinical and laboratory observations in cases of
triiodothyronine toxicosis confirmed by radioimmunoassay.
Lancet 1972;1(7751):609-11.
Sterling K, Refetoff S, Sleekness HA. T3 thyrotoxicosis.
Thyrotoxicosis due to elevated serum triiodothyronine
levels. JAMA 1970;213:571-5.
Tietz, NW. Clinical Guide to Laboratory Test. 3rd Edition.
Philadelphia; W B Saunder & Co: 1995. p. 612.
Burroughs, V.; Shenkman, L. Thyroid function in the
elderly. Am J Med Sci 1982;283:8-17.
Burger HG, Patel TC. Thyrotrophin releasing hormone--
TSH. Clin Endrocrinol Metab 1977;6(1):83-100.
Klee GG, Hay ID. Assessment of sensitive thyrotropin
assays for an expanded role in thyroid function testing:
proposed criteria for analytic performance and clinical
utility. J Clin Endocrinol Metab 1987;64(3):461-71
Muslim S, Khalil Z. Effect of Age, Sex, Salt, Water and
Climate on T3, T4 and TSH in Healthy Individuals,
Department of Zoology Peshawar University; 2000.
Franklyn JA, Ramsden BD, Sheppard MC. The influence of
age and sex on tests of thyroid function. Am Clin Biochem
;22:502-5.
Nissinen A, Kivelä SL, Pekkanen J, Pitkänen L, Punsar S,
Kaarsalo E, et al. Thyroid function tests in elderly Finnish
men. Acta Med Scand 1986;220:63-9.
Westgren U, Burger A, Ingemansson S, Melander A, Tibblin
S, WÃ¥hlin E. Blood levels of 3,5,3'-triiodothyronine and
thyroxine: differences between children, adults, and elderly
subjects. Acta Med Scand 1976;200:493-5.
Hesch RD, Gatz J, Pape J, Schmidt E, von zur Mühlen A.
Total and free triiodothyronine and thyroid-binding globulin
concentration in elderly human persons. Eur J Clin Invest
;6(2):139-45.
Hoogendoorn EH, Hermus AR, de Vegt F, Ross
HA, Verbeek AL, Kiemeney LA, et al. Thyroid function and
prevalence of anti-thyroperoxidase antibodies in a population
with borderline sufficient iodine intake: influences of age
and sex. Clin Chem 2006;52:104-11.
Sack J, Bar-On Z, Shemesh J, Becker R. Serum T4, T3 and
TBG concentrations during puberty in males. Eur J Pediatr
;138(2):136-7.
Campbell AJ, Reinken J, Allan BC. Thyroid disease in the
elderly in the community. Age Ageing 1981;10:47-52.
Penny R, Spencer CA, Frasier SD, Nicoloff, JT. ThyroidStimulating Hormone and Thyroglobulin Levels Decrease
with Chronological Age in Children and Adolescents. J Chin.
Endocrinol. Metab 1983; 56(1):177-80.
Hershman JM, Pekary AE, Berg L, Solomon DH, Sawin
CT. Serum thyrotropin and thyroid hormone levels in elderly
and middle-aged euthyroid persons. J Am Geriatr Soc
;41:823-8.
Downloads
Published
How to Cite
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.