INFLUENCE OF SIBUTRAMINE, ORLISTAT AND ISPAGHULA IN REDUCING BODY WEIGHT AND TOTAL BODY FAT CONTENT IN OBESE INDIVIDUALS
Abstract
Background: The correlations between combined body fat parameters and risk factors of obesityexplained a portion of the variation in the weight, BMI and waist circumference, the average
number of categorical metabolic risk factors increases progressively with increasing total body fat
content. There is currently no data available in which influence of drugs can be assessed on total
body fat content. This was a non-randomized, prospective, open-label, parallel group study was
conducted to compare the effectiveness of sibutramine, orlistat and ispahgula in reducing body
weight and percentage of total body fat content in obese individuals. Methods: A nonrandomized,
open label, prospective, intention to treat clinical trial was conducted from July 2008 to March
2009 in JPMC, Karachi, Pakistan. The study was based on three arms A (ispahgula), B (orlistat)
and C (sibutramine) comprising 40 patients in each. The selection criteria has included patients
from either sex with age 18 years or more with BMI ‰¥30 as obese with or without associated risk
factors and BMI ‰¥27 <30 as over weight only if any significant risk factor is present. Compliance
on diet chart and instruction for life style modification were assessed monthly. Results: The
comparison of mean difference in percentage of total body fat content between the groups and
within the groups at day 150 is (p-value) 0.029 and difference in body weight is (p-value) 0.042
which is statistically significant. Conclusion: Sibutramine is more effective than ispahgula and
orlistat in reducing body weight and percentage of total body fat content in obese patients.
Keywords: Sibutramine, Orlistat, Ispahgula, body weight and obesity.
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