OXIDATIVE STRESS AND LEVEL OF IRON INDICES IN CORONARY HEART DISEASE PATIENTS
Abstract
Objective: Oxidative stress is characterized by an increased concentration of oxygen free radicalswhich can cause a critical, or even an irreversible, cell injury. The study was designed to determine
and compare the levels of oxidative stress and iron indices in Coronary Heart Disease and healthy
individuals. Material and Methods: Blood malondialdehyde, iron, total iron-binding capacity,
transferrin saturation and ferretin levels were determined in 140 Coronary Heart Disease and 100
healthy subjects. Results: Values of blood malondialdehyde, iron, transferrin saturation and ferretin
were observed to be significantly increased with exception of total iron-binding capacity, which was
significantly decreased (p0.005) in Coronary Heart Disease patients when compared with normal
healthy controls. Conclusion: Elevated serum malondialdehyde, iron concentration and body iron
stores in patients reveal a possible role of iron indices in the development of coronary
atherosclerosis. Therefore, it is suggested by this study that levels of malondialdehyde and
biochemical markers of body iron stores can be used as an early investigative tool for assessing the
oxidative stress in coronary heart disease.
Keywords: Coronary Heart Disease, Oxidative Stress, Malondialdehyde, Iron, Total iron-binding
capacity, Transferrin Saturation, Ferritin
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