DETECTION OF ATHEROSCLEROSIS BY ANKLE BRACHIAL INDEX: EVALUATION OF PALPATORY METHOD VERSUS ULTRASOUND DOPPLER TECHNIQUE
Abstract
Background: Peripheral Arterial Disease [PAD], a manifestation of systemic atherosclerosis, is highlyprevalent both in community studies and in primary care practice. Estimation of ankle brachial index
[ABI] by ultrasound Doppler is the standard screening method for the detection of atherosclerosis in PAD
patients. A low ABI is associated with increased risk of stroke or transient ischemic attack, ischemic heart
disease and lower extremity gangrene. Though prevalence is high, physician and patient awareness of the
condition is low. Primary care physicians are not well versed with the use of Doppler. Initial cost of the
equipment is another adverse factor in low income countries. Detection of ankle systolic pressure by
palpatory method may offer a cheap, simple and useful alternative approach in office care settings for
early detection of disease. This may lead to the use of risk reduction strategies to avoid significant future
morbidity and mortality. Methods: The sample size of 230 participants was identified. Patients were
divided into control (100 cases), high risk asymptomatic (100 cases) and symptomatic groups (30 cases).
Ankle systolic pressure was measured by digital palpation of foot arteries and by the gold standard
Doppler technique in all patients in the three groups. PAD was defined by an ABI of <0.9. Results: In
control group, mean±SD value of ABI was 1.0115±0.08167 by Doppler method versus 0.9923±0.08609
by palpatory method (p=0.1), in high risk asymptomatic group, 0.9838±0.08878 versus 0.9608±0.10377
(p=0.13) and in symptomatic group, 0.9302±0.14064 versus 0.9088±0.13274 (p=0.12). Against the more
precise Doppler method, palpatory method was equally good in detecting the PAD positive cases.
Conclusion: Early diagnosis of PAD in primary care practice by manual palpation of foot arteries is a
reliable method to identify the population at risk and may lead to aggressive preventive therapies.
Keywords: Peripheral arterial disease, cardiovascular disease, risk factors, ankle blood pressure,
ankle brachial index.
References
Faxon DP, Fuster V, Libby P, Beckman JA, Hiatt WR,
Thompson RW, Topper JN Annex BA, Rundback JH,
Fabunmi RP, Robertson RM and Loscalzo J Atherosclerotic
Vascular Disease Conference. Writing Group III:
Pathophysiology. Circulation 2004;109:2617-25.
Lusis AJ. Atherosclerosis. Nature 2000;407:233-41.
Balkau B. Vary M. Eschwege E. Epidemiology of peripheral
arterial disease. J. Cardiovasc Pharmacol 1994;23(Suppl-3):S8-16.
Hirsch AT, Griqui MH, Jacobson DT, Regensteiner JG,
Greager MA, Olin JW. Peripheral arterial disease detection
awareness and treatment in primary care. JAMA
;286:1317-24.
Vogt MT, McKenna M, Wolfson SK, Kuller LH. The
relationship between ankle brachial index, other atherosclerotic
disease, diabetes, smoking and mortality in older men and
women. Atherosclerosis 1993;101:191-202.
J Ayub Med Coll Abbottabad 2009;21(1)
http://www.ayubmed.edu.pk/JAMC/PAST/21-1/Bilquis.pdf
Kenneth Ouriel. Detection of peripheral arterial disease in
primary care. JAMA 2001;286:1380-1.
Hiatt WR, Hoag S, Hamman RF. Effect of Diagnostic Criteria
on the prevalence of Peripheral Arterial Disease: The San Luis
Valley Diabetes Study. Circulation 1995;91:1472-9.
McDermott MM, Greenland PH, Liu K, Guralnik JM, Celic L,
Criqui MH. The ankle brachial index is associated with leg function
and physical activity. Ann Intern Med 2002;136:387-8.
Curb DJ, Kamal Masaki, Beatriz I, Rodriguez, Robert D,
Abbot, et al. Peripheral arterial disease and cardiovascular
factors in the elderly The Honolulu Heart Program.
Atherosclerosis, Thrombosis and Vascular Biology
;16:1495-500.
Criqui MH, Fronek A, Klauber MR, Barrett-Connor E and
Gabriel S. The sensitivity, specificity and predictive value of
traditional clinical evaluation of peripheral arterial disease:
results from non invasive testing in a defined population.
Circulation 1985;71(3):516-22.
Powers KB, Vacek JL and Lee S. Noninvasive approaches to
Peripheral Vascular Disease. Postgraduate Medicine
;106(3):1-13.
Barnes RW. Noninvasive Diagnostic Assessment of Peripheral
Vascular Disease. Circulation 1991;83 (2suppl):120-7.
Blumenthal RS, Becker DM, Yanek LR, Aversano TR, Moy
TF, Kral BG, et al. Detecting occult coronary disease in a high
risk asymptomatic population. Circulation 2003;107:702-7.
Fowkes FGR, Housby E, Cawood EHH, Macintyre CCA,
Ruckley CV, Prescott RJ. Edinburgh artery study: prevalence
of asymptomatic and symptomatic peripheral arterial disease in
the general population. International Journal of Epidemiology
;20:384-92.
Federman DG, Bravata DM, Kirsner RS. Peripheral arterial
disease, a systemic disease extending beyond the affected
extremity. Geriatrics 2004;59:26-35.
Stoffers HEJ, Rinkens PELM, Kester ADM, Kaiser V,
Knottnerus JA. The prevalence of asymptomatic and
unrecognized peripheral arterial occlusive disease. Int J
Epidemiol 1996;25:282-90.
Stoffers HEJ, Kester ADM, Kaiser V, Rinkens P, Kittslaar
PJEHM, Knottnerus JA. Diagnostic value of the measurement
of the ankle brachial systolic pressure index in primary health
care. Journal of Clinical Epidemiology 1996;49(12):1401-5.
Leng GC, Fowkes FGR, Lee AJ, Dunber J, Housely E,
Ruckley CV. Use of ankle brachial pressure index to predict
cardiovascular events and death. Br Med J 1996;313:1440-3.
Ostergren J, Sleight P, Dagenais G, Danisa K, Bosch J, Oilong
Y, et al. Impact of ramipril in patients wth evidence of clinical
or sub clinical peripheral arterial disease. European Heart J
;25:17-24.
Bashir, Riyaz; Cooper, Christopher J. Evaluation and medical
treatment of peripheral arterial disease. Current Opinions in
Cardiology 2003;18(6):436-43.
Selvin E, Thomas P and Erlinger. Prevalence of and risk
factors for peripheral arterial disease in the United States.
Circulation 2004;110:738-43.
Published
How to Cite
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.