GESTATIONAL TROPHOBLASTIC DISEASE: EXPERIENCE AT NAWABSHAH HOSPITAL

Authors

  • Khairunnisa Nizam
  • Gulfareen Haider
  • Nizamuddin Memon
  • Ambreen Haider

Abstract

Background: Gestational Trophoblastic Disease (GTD) is a heterogeneous group of diseases that
includes partial and complete hydatidiform mole, invasive mole, choriocarcinoma and placental site
trophoblastic tumour. The incidence of GTD varies in different parts of the world. The malignant
potential of this disease is higher in South East Asia in comparison to western countries. Objectives of
study were to determine the frequency, clinical presentation and management outcomes of GTD. This
retrospective, descriptive case series was conducted in the Department of Obstetric and Gynaecology
Nawabshah Medical College Hospital, from 1st Jan 2007 to 30th Dec 2007. Methods: The case records
of all the gestational trophoblastic cases during study period were analysed regarding their history,
clinical examination, investigations, treatment and follow-up. The main outcomes were measured in
terms of duration, antecedent pregnancy, investigations, treatment and the follow-up. Results: There
were a total of 1056 Obstetric admissions during the study period, which included 30 cases of
trophoblastic disease with a frequency of GTD was 28 per 1000 live births. Of these 30 cases, 21 (70%)
patients had hydatidiform mole, 7 (23.3%) patients had invasive disease and 2 (6.6%) patients had
choriocarcinoma. Twenty three patients (76.6%) received chemotherapy while 25 (83.3%) patients had
suction evacuation and 4 (13.3%) patients underwent hysterectomy. Among all patients, 29(96.7%)
fully recovered and 1 (3.3%) died because of extensive disease; metastasis extending up to brain.
Conclusion: Frequency of GTD was higher compared to national and international studies. The disease
was common in extremes of ages, low para and grand multiparous women. Hydatidiform mole was the
commonest type of trophoblastic disease in these patients. Most common presenting complaint was
bleeding per vagina followed by pain in lower abdomen.
Keywords: Gestational trophoblastic disease, Hydatidiform mole, Management.

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Published

2009-03-01

How to Cite

Nizam, K., Haider, G., Memon, N., & Haider, A. (2009). GESTATIONAL TROPHOBLASTIC DISEASE: EXPERIENCE AT NAWABSHAH HOSPITAL. Journal of Ayub Medical College Abbottabad, 21(1), 94–97. Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/3790

Issue

Vol. 21 No. 1 (2009): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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