SQUAMOUS CELL CARCINOMA OF THE CONJUNCTIVA: ANALYSIS OF FIFTEEN CASES

Authors

  • Mirza Shafiq Ali Baig
  • Shehla Dareshani
  • Mir Amjad Ali
  • Mohammad Shafique Khan

Abstract

Background: To document various clinical presentations and management options of
conjunctival squamous cell carcinoma (CSCC) in patients attending ophthalmic out patients
department (OPD) of a tertiary care centre. This case series was carried out in the Department of
Ophthalmology Civil Hospital and, Dow University of Health Sciences, Karachi and were
reviewed from June 2004 to December 2007. Methods: Socio-demographic data and clinical
features of patients with biopsy proven conjunctival squamous cell carcinoma were recorded and
analysed. All patients underwent complete ophthalmic examination by a fellow ophthalmologist
and clinical findings were recorded on a prescribed Performa. Data was analysed in terms of
frequency, means and median by SPSS for windows V.15. Results: Seventy-two percent of the
patients were male and 28% were female, more than 80% of patients were in the age group of
seventy years and above. Eighteen percent of patients developed intraocular invasion and the eyes
had to be enucleated. Conclusion: CSCC occurs in sun damaged ocular surface usually at limbus,
elderly men are more commonly involve, recurrence is a feature of disease and high risk in older
individual. In our treatment we used various therapies, excision with clear margin, topical
mitomycin C adjunctive cryotherapy and amniotic graft.
Keywords: Conjunctival squamous cell carcinoma, elderly men, clinical presentations, recurrence,
management options

References

Yang J, Foster CS. Squamous cell carcinoma of the

conjunctiva. Int Ophthalmol Clin 1997;37(4):73-85.

McKelvie PA, Daniell M, McNab A, Loughnan M,

Santamaria JD. Squamous cell carcinoma of the conjunctiva:

a series of 26 cases. Br J Ophthalmol 2002;86:168-73

Lee GA Hirst LW. Retrospective study of ocular surface

neoplasia. Aust NZ J Ophthalmol 1997;25:269-76.

Sen S, Sharma A, Panda A. Immunohistochemical

localization of human papilloma virus in conjunctival

neoplasias: a retrospective study. 1. Indian J Ophthalmol

;55:361-3.

Kanski JJ. Conjunctiva. In: Clinical Ophthalmology: 6th ed.

Oxford: Butterworth-Heinemann; 2007.p.37-44.

Ramasamy B, Quah SA, Wishart MS, Hiscott P. Temporal

pterygium: benign or not? Br J Ophthalmol 2005;89:1533-4.

Siddiqi S, Kielmann AA, Khan MS, Ali N, Ghaffar A,

Sheikh U et al. The effectiveness of patient referral in

Pakistan. Health Policy Plan 2001;16:193-8.

Tulvatana W, Bhattarakosol P, Sansopha L, Sipiyarak W,

Kowitdamrong E, Paisuntornsug T, et al. Risk factors for

conjunctival squamous cell neoplasia: a matched case-control

study. 20: Br J Ophthalmol 2003;87(4):396-8.

Poole TR. Conjunctival squamous cell carcinoma in

Tanzania. Br J Ophthalmol 1999;83:177-9.

Tunc M, Char DH, Crawford B, Miller T. Intraepithelial and

invasive squamous cell carcinoma of the conjunctiva:

analysis of 60 cases. Br J Ophthalmol 1999;83:98-103.

Khong JJ, Muecke J.Complications of mitomycin C therapy

in 100 eyes with ocular surface neoplasia. Br J Ophthalmol

;90:819-22.

Beby F, Kodjikian L, Roche O, Bouvier R, Donate D,

Guerillon F, et al. Conjunctival tumors in children. A

histopathologic study of 42 cases. J Fr Ophtalmol

;28:817-23.

Finger PT. "Finger-tip" cryotherapy probes: treatment of

squamous and melanocytic conjunctival neoplasia. Br J

Ophthalmol 2005;89(8):942-5.

Bajaj M S, Panda A, Pushker N, Balasubramanya R. Amniotic

membrane transplantation. Br J Ophthalmol 2002;86:1460.

Published

2009-03-01

How to Cite

Baig, M. S. A., Dareshani, S., Ali, M. A., & Khan, M. S. (2009). SQUAMOUS CELL CARCINOMA OF THE CONJUNCTIVA: ANALYSIS OF FIFTEEN CASES. Journal of Ayub Medical College Abbottabad, 21(1), 146–147. Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/3804