KI-67 PROLIFERATING INDEX AND HISTOLOGICAL GRADE, TYPE AND STAGE OF COLORECTAL CARCINOMA

Authors

  • Uzma Nabi
  • A H Nagi
  • Waqas Sami

Abstract

Background: The objective of this study was to assess the relationship of histological type, grade and
stage of colorectal carcinoma with proliferative activity as measured by Ki-67 LI. It was a descriptive
study and conducted at the Department of Pathology, University of Health Sciences, Lahore. Methods:
Ki-67 is a protein associated with cell proliferation and is expressed in all the phases of cell cycle except
G0. In the present study, Ki-67 expression in 50 patients with colorectal adenocarcinomas was observed
using immunohistochemistry with monoclonal antibody MIB-1. Results: Ki-67 LI was high in well and
moderately differentiated adenocarcinomas (mean Ki-67 LI 392.50± 56.58 and 342.24±96.84
respectively) as compared to poorly differentiated adenocarcinomas (mean Ki-67 LI 250.00±113.46). Ki-
67 LI was high in non mucinous adenocarcinomas than mucin secreting and signet ring cell
adenocarcinomas (mean Ki-67 393.93±55.91 vs 220.00±49.72 and 200.00±79.05 respectively). As regard
the Dukes' staging, Ki-67 LI was high in colorectal carcinomas in Dukes' stage B than tumours in Dukes'
stage C (Mean Ki-67 LI 360.13±90.03 vs 241.66±101.31 respectively). Conclusion: The proliferative
activity as measured by Ki-67 antibody is related to histological type, grade and stage.
Keywords: Colorectal carcinoma, Grade, Proliferation index, Immunohistochemistry, Ki-67

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Published

2008-12-01

How to Cite

Nabi, U., Nagi, A. H., & Sami, W. (2008). KI-67 PROLIFERATING INDEX AND HISTOLOGICAL GRADE, TYPE AND STAGE OF COLORECTAL CARCINOMA. Journal of Ayub Medical College Abbottabad, 20(4), 44–48. Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/3841

Issue

Vol. 20 No. 4 (2008): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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