ROLE OF PARACETAMOL AGAINST THE EROSIVE ACTION OF RECTIFIED SPRIT ON STOMACH IN ALBINO RATS
Abstract
ABSTRACTThe protective role of paracetamol against rectified spirit (nonspecific injuring
agent) on the gastric mucosa of albino rat was observed under dissecting as well as
laboratory micro-scope. A dose of250 mg/kg body weight provided complete protection
under dissecting micro-scope. However, gum acacia with rectified spirit treatment
provided significant decrease in the erosion score. Under laboratory microscope a
significant increase in the thickness of the mucosa was observed in combined treatment
of paracetamol with rectified spirit as compared to rectified spirit alone or gum acacia
with rectified spirit. A slight exfoliation and flattening of the surface epithelium may
probably be due to increase in the secretory activity of chief cells. A significant increase
in the secretory activity of the mucous neck cells in the group treated with rectified spirit
plus paracetamol may be attributed to the increased bio-synthesis of prostaglandin from
the mucous neck cell, which provides partial protective role against ulcerogenic agent.
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