DETECTION OF β-THALASSAEMIA TRAIT: ASTI DY OF FIFTY FEMALES

Authors

  • SHAHID ANJUM
  • MUHAMMD TAQYYAB
  • SYED HUMAYUN SHAH
  • NASEER CHAUDHRY

Abstract

Background: his study was carried out to detect beta-thalassaemia frail in the siblings of beta thalassaemia major
children by Hemoglobin (Hb) electrophoresis Methods: Subjects were divided into two groups Group I Mas the
patterns group comprising 100-subjects siblings of beta- thalassaemia major children and Group 2 was the control
group with 25-subjects Results: It was observed that 58% of the siblings of beta-thalassaemia major children had betathalassaemia trail Even in the control group 2 subjects had beta thalassaemia trait which shows that thalassaemia gene
is very common in Hazara division of Pakistan.

References

Clegg JB. Weatherall DJ. Molecular basis of

thalassaemia Br Med. Bull 1976; 32(2):262-69.

Clegg JB. The molecular defect in thalassaemia.

Ann Int Med 1972; 80:97-101.

Ritchey AK, Hoffman R et al. Imbalanced globin

chain synthesis in cultured erythroid progenitor

cells from thalassaemic bone marrow and

peripheral blood. Blood 1981 ;54 (4):788-93.

Schwartz E. The silent carrier of β-thalassemia N

Eng. J Med. 1969: 281: 1327 - 33

Fosburg MT, Nathan DG, Treatment of Cooley

anaemia. Blood 1990; 76 (3) 435-44.

Weatherall DJ, Pressle L, Wood WJ, Higgs DR,

Clegg TB, Molecular basis for mild form of

homozygous β-Thalassaemia. Lancet 1981; 527 -

Gazzela M, Dezza L, Bergamaschi G et. Al.,

Biological and clinical significance of red cell

ferritin, Blood 1983; 62 (5): 1078-87.

Pearson HA, O'Brien R, Mclntoshet, SM,

Screening Thalassemia in Sardinia. Clin Genet

; 36: 277-85.

Buki MK, Qayum 1, Siddique N, Prevalence and

preventive measures for thalassemia in Hazara

region of NWFP Pakistan. JAMC 1998; 10 (1): 28

- 31.

Modell, CB. Practical approaches to the control of

thalassemia. Lancet 1972: 105-11.

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How to Cite

ANJUM, S., TAQYYAB, M., SHAH, S. H., & CHAUDHRY, N. (2001). DETECTION OF β-THALASSAEMIA TRAIT: ASTI DY OF FIFTY FEMALES. Journal of Ayub Medical College Abbottabad, 13(2). Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/4846