EXPERIMENTAL STUDY OF CADMIUM INDUCED HEPATIC TOXICITY

Authors

  • Khawaja Usman Masud
  • A. H. Nagi

Abstract

Background: Cadmium is a modern toxic metal. It is a proven environmental pollutant and has hepatotoxic effects as
well. This study was carried out to look for hepatotoxicity of cadmium in rabbits. Methods: Forty rabbits divided into
four equal groups (3 experimental and 1 control) were used. Minimum Lethal dose and experimental dose of Cadmium
Sulphate were calculated. Group I was injected with half minimal lethal dose, Group II with experimental dose and
Group III with 30% specific bovine albumin, followed by experimental dose. The control group was injected with
distilled water. This treatment was continued for 12 weeks. During the experiment serum alanine transferase (S-ALT)
and gamma glutamide transpeptidase (y-GT) were estimated twice, at intervals of 6 weeks and 12 weeks followed by
autopsy at the end of the experiment. The liver was excised after sacrificing the animals. The tissue was processed for
histopathology. Results: A definite rise in the enzymes and changes in normal liver histology were observed.
Conclusions: The cadmium induced lesions in the liver appear to be dose and time dependent. The findings of this
study suggest that cadmium has direct toxic effects on liver leading to hepatic damage. It is therefore recommended
that the environmental cadmium pollution and uncontrolled industrial use of this metal must be controlled.

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How to Cite

Masud, K. U., & Nagi, A. H. (2000). EXPERIMENTAL STUDY OF CADMIUM INDUCED HEPATIC TOXICITY. Journal of Ayub Medical College Abbottabad, 12(1). Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/5211

Issue

Vol. 12 No. 1 (2000): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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