THE ROLE OF RS12901499 POLYMORPHISM IN ASSOCIATION WITH SMAD3 GENE AND OSTEOARTHRITIS SUSCEPTIBILITY: SYSTEMATIC REVIEW AND META-ANALYSIS
Abstract
Background: Osteoarthritis is regarded as one of the most frequent disorders of
musculoskeletal, which is characterized by the degeneration of articular cartilage and loss
of cartilage of the joints. However, the relationship of OA susceptibility with rs12901499
polymorphism in SMAD3 is controversial. Although multiple studies have investigated the
correlation of rs12901499A/G polymorphism in SMAD family member 3 (SMAD3) and
osteoarthritis (OA) susceptibility, the results from previous studies remain controversial and
unsolved. A meta-analysis utilizing fixed and random effects model was performed to clarify
the association. Methods:Eligible studies were systematically searched from PubMed, Web
of Science, Cochrane Library and EMBASE on April 17, 2019 for reporting the correlation of
rs12901499 polymorphism and osteoarthritis susceptibility. Pooled Odds ratio of 95%
confidence interval was performed to estimate the strength of relationship of rs12901499
polymorphism and osteoarthritis susceptibility. Publication bias was detected by Begg's test
and STATA 11.0 software was used to evaluate statistical analysis. Results: Seven casecontrol papers involving eight studies from Caucasian and Asian populations were included. A
significant increase in osteoarthritis susceptibility was found in recessive, homozygous and
allele models. Stratified analysis on ethnicity suggested that the polymorphism with increased
risk of OA only in Asians under allele model. Stratified analysis related to population-based
studies indicated the increased risk of OA with polymorphism in recessive, homozygous,
allele and dominant models. Conclusion:This meta-analysis demonstrated that there may be
a weak association of rs12901499 polymorphism and OA susceptibility. Due to the limited
size of sample and given ethnic groups, more studies need to validate the result in future.
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